ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for associated out of >500 occurrences
657704 occurrences (No.10 in the rank) during 5 years in the PubMed. [cache]
427) In addition to imiquimod-associated adverse effects at non-application sites such as fever, vertigo or myalgia there have been anecdotal reports of distant inflammatory mucosal reactions-a side effect not declared in the medicinal product information.
* Mucosal side effects in patients treated with topical imiquimod-A scoping review of the literature.
- Imiquimod 5% is approved for topical treatment of actinic keratosis (AKs), superficial basal cell carcinoma and condylomata acuminata, the 3.75% formulation for the treatment of AKs and genital warts. Imiquimod has also been used off-label in various other skin conditions (eg, Bowen's disease, lentigo maligna, vulvar intraepithelial neoplasia). As a toll-like receptor 7/8 (TLR7/8) agonist imiquimod induces a local inflammatory response by increased production of cytokines, co-stimulatory molecules, activation of Nk-cells and antigen-specific T-cells. In addition to imiquimod-associated adverse effects at non-application sites such as fever, vertigo or myalgia there have been anecdotal reports of distant inflammatory mucosal reactions-a side effect not declared in the medicinal product information. In this scoping review we collected a total of seven cases of patients with lesions of the oral mucosa and lips and summarized pathophysiological hypotheses to explain this type of side effect. The review is complemented with an illustrated report of a 87-year-old female patient of ours suffering from chronic lymphocytic leukemia (CLL) who developed severe oral mucosal and labial reactions following application of imiquimod 3.75% for treatment of AKs. She denied accidental transfer of imiquimod and was tested negative for herpes simplex virus (PCR) and bacteria (culture) from lesional swabs.
Overview of verb associate
The verb associate has 3 senses (first 3 from tagged texts)
1. (25) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal
connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I
cannot relate these events at all")
2. (3) consort, associate, affiliate, assort -- (keep company with; hang out with; "He associates
with strange people"; "She affiliates with her colleagues")
3. (1) consociate, associate -- (bring or come into association or action; "The churches consociated
to fight their dissolution")
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