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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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657704 occurrences (No.10 in the rank) during 5 years in the PubMed. [cache]
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[frequency of next (right) word to associated]
657704 occurrences (No.10 in the rank) during 5 years in the PubMed. [cache]
| 429) However, previous studies on the ability of P-gp to directly transport the Alzheimer's associated amyloid-β (Aβ) protein have produced contradictory results. |
| PMID:33901197 DOI:10.1371/journal.pone.0250371 |
| 2021 PloS one |
| * Transport of Alzheimer's associated amyloid-β catalyzed by P-glycoprotein. |
| - P-glycoprotein (P-gp) is a critical membrane transporter in the blood brain barrier (BBB) and is implicated in Alzheimer's disease (AD). However, previous studies on the ability of P-gp to directly transport the Alzheimer's associated amyloid-β (Aβ) protein have produced contradictory results. Here we use molecular dynamics (MD) simulations, transport substrate accumulation studies in cell culture, and biochemical activity assays to show that P-gp actively transports Aβ. We observed transport of Aβ40 and Aβ42 monomers by P-gp in explicit MD simulations of a putative catalytic cycle. In in vitro assays with P-gp overexpressing cells, we observed enhanced accumulation of fluorescently labeled Aβ42 in the presence of Tariquidar, a potent P-gp inhibitor. We also showed that Aβ42 stimulated the ATP hydrolysis activity of isolated P-gp in nanodiscs. Our findings expand the substrate profile of P-gp, and suggest that P-gp may contribute to the onset and progression of AD. |
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(1)376  with |
(6)3 risk |
(11)2 immune |
(16)2 osteosarcoma |
| (2)4 diseases |
(7)2 at |
(12)2 liver |
(17)2 receptor |
| (3)4 genes |
(8)2 cancers |
(13)2 lymphoid |
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| (4)4 protein |
(9)2 common |
(14)2 macrophage |
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| (5)3 genes, |
(10)2 diarrhoea |
(15)2 molecular |
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--- WordNet output for associated ---