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657704 occurrences (No.10 in the rank) during 5 years in the PubMed. [cache]

435) Obesity-associated breast cancer recurrence is mechanistically linked with elevated insulin levels and insulin resistance.

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PMID:34578984 DOI:10.3390/nu13093108

2021 Nutrients

* WISER Survivor Trial: Combined Effect of Exercise and Weight Loss Interventions on Insulin and Insulin Resistance in Breast Cancer Survivors.

- Obesity-associated breast cancer recurrence is mechanistically linked with elevated insulin levels and insulin resistance. Exercise and weight loss are associated with decreased breast cancer recurrence, which may be mediated through reduced insulin levels and improved insulin sensitivity. This is a secondary analysis of the WISER Survivor clinical trial examining the relative effect of exercise, weight loss and combined exercise and weight loss interventions on insulin and insulin resistance. The weight loss and combined intervention groups showed significant reductions in levels of: insulin, C-peptide, homeostatic model assessment 2 (HOMA2) insulin resistance (IR), and HOMA2 beta-cell function (β) compared to the control group. Independent of intervention group, weight loss of ≥10% was associated with decreased levels of insulin, C-peptide, and HOMA2-IR compared to 0-5% weight loss. Further, the combination of exercise and weight loss was particularly important for breast cancer survivors with clinically abnormal levels of C-peptide.

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(1)376 with	(6)3 risk	(11)2 immune	(16)2 osteosarcoma
(2)4 diseases	(7)2 at	(12)2 liver	(17)2 receptor
(3)4 genes	(8)2 cancers	(13)2 lymphoid
(4)4 protein	(9)2 common	(14)2 macrophage
(5)3 genes,	(10)2 diarrhoea	(15)2 molecular

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--- WordNet output for associated --- Overview of verb associate The verb associate has 3 senses (first 3 from tagged texts) 1. (25) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all") 2. (3) consort, associate, affiliate, assort -- (keep company with; hang out with; "He associates with strange people"; "She affiliates with her colleagues") 3. (1) consociate, associate -- (bring or come into association or action; "The churches consociated to fight their dissolution") --- WordNet end ---