ELIZA

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657704 occurrences (No.10 in the rank) during 5 years in the PubMed. [no cache] 500 found

461) Individual differences in striatal dopamine (DA) signaling have been associated both with individual differences in executive function in healthy individuals and with risk for psychiatric disorders defined by executive dysfunction.

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PMID:23968837 DOI:10.1093/cercor/bht229

2015 Cerebral cortex (New York, N.Y. : 1991)

* Resting-state striato-frontal functional connectivity is sensitive to DAT1 genotype and predicts executive function.

- Individual differences in striatal dopamine (DA) signaling have been associated both with individual differences in executive function in healthy individuals and with risk for psychiatric disorders defined by executive dysfunction. We used resting-state functional connectivity in 50 healthy adults to examine whether a polymorphism of the dopamine transporter gene (DAT1), which regulates striatal DA function, affects striatal functional connectivity in healthy adults, and whether that connectivity predicts executive function. We found that 9/10 heterozygotes, who are believed to have higher striatal DA signaling, demonstrated stronger connectivity between dorsal caudate (DC) and insular, dorsal anterior cingulate, and dorsolateral prefrontal regions, as well as between ventral striatum and ventrolateral prefrontal cortex, than 10/10 homozygotes. Across subjects, stronger DC-seeded connectivity predicted superior N-back working memory performance, while stronger ventral striatum-seeded connectivity predicted reduced impulsivity in everyday life. Further, mediation analysis suggested that connectivity strength mediated relationships between DAT1 genotype and behavior. These findings suggest that resting-state striato-frontal connectivity may be an endophenotype for executive function in healthy individuals.

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(1)421 with	(4)3 sequence,	(7)2 environmental	(10)2 renal
(2)5 risk	(5)3 sequences	(8)2 microorganisms
(3)5 sequence	(6)2 and	(9)2 neurological

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--- WordNet output for associated --- Overview of verb associate The verb associate has 3 senses (first 3 from tagged texts) 1. (25) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all") 2. (3) consort, associate, affiliate, assort -- (keep company with; hang out with; "He associates with strange people"; "She affiliates with her colleagues") 3. (1) consociate, associate -- (bring or come into association or action; "The churches consociated to fight their dissolution") --- WordNet end ---