316) Medical records of 77 dogs with multi-centric lymphoma treated with a CHOP-based chemotherapy protocol were retrospectively evaluated. |
PMID:23786518 DOI:10.1111/vco.12045 |
2015 Veterinary and comparative oncology |
* Prognostic value of baseline absolute lymphocyte concentration and neutrophil/lymphocyte ratio in dogs with newly diagnosed multi-centric lymphoma. |
- Canine multi-centric B-cell lymphoma shares similarities with diffuse large B-cell (Non-Hodgkin's) lymphoma (NHL) in people. In people with NHL, lymphopenia at diagnosis and first relapse and neutrophil/lymphocyte ratio (N:L) > 3.5 are negative prognostic factors for survival. The objective of this study was to determine if lymphocyte concentration at diagnosis and first relapse and N:L were prognostic for survival in dogs with newly diagnosed multi-centric lymphoma. Medical records of 77 dogs with multi-centric lymphoma treated with a CHOP-based chemotherapy protocol were retrospectively evaluated. Absolute lymphocyte concentration and N:L ratio at presentation of dogs pre-treated with steroids was not significantly different from dogs who had not received steroids. On multivariate analysis, only immunophenotype remained significant for progression-free survival (PFS), whereas no variables remained significant for ST. A prospective study of these haematologic variables is warranted to assess their true significance. |
(1)247 on | (10)3 approach | (19)2 chemotherapy | (28)2 physical |
(2)10 method | (11)3 hydrogels | (20)2 computer-tailored | (29)2 rehabilitation |
(3)10 therapies | (12)3 information | (21)2 financing | (30)2 retrospective |
(4)5 cross-sectional | (13)3 study | (22)2 learning | (31)2 scaffolds |
(5)5 upon | (14)3 techniques | (23)2 methods | (32)2 strategy |
(6)4 survey | (15)3 therapeutic | (24)2 modelling | (33)2 studies |
(7)4 tissue | (16)2 NPWT | (25)2 morphometry | (34)2 telephone |
(8)3 CRT | (17)2 RUTF | (26)2 nutrient | (35)2 vaccination |
(9)3 anti-bullying | (18)2 and | (27)2 palliative |
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