* Unusual genetic aberrations including a deletion of KLF6 tumor suppressor gene revealed by integrated cytogenetic approaches in a pediatric ewing sarcoma.
- Ewing sarcoma is the third most common sarcoma in children and young adults. Its characteristic chromosomal rearrangement results in a chimerical EWSR1-ETS transcription factor. Secondary genetic alterations are very common. Membranous expression of CD99 is seen in almost all tumors. We report 2 unusual cytogenetic findings in a pediatric Ewing sarcoma, an insertion of the MIC2 gene encoding CD99 from Xp to 10p and a submicroscopic deletion of the well-known tumor supressor gene KLF6. The latter has not been described previously in pediatric neoplasms. Molecular pathways in tumorigenesis and genetic complexity in cancer are discussed.
=>【病名】がん, 悪性腫瘍(しゅよう), がん腫, 社会悪, 癌
Overview of noun cancer
The noun cancer has 5 senses (first 1 from tagged texts)
1. (15) cancer, malignant neoplastic disease -- (any malignant growth or tumor caused by abnormal
and uncontrolled cell division; it may spread to other parts of the body through the lymphatic
system or the blood stream)
2. Cancer, Crab -- ((astrology) a person who is born while the sun is in Cancer)
3. Cancer -- (a small zodiacal constellation in the northern hemisphere; between Leo and Gemini)
4. Cancer, Cancer the Crab, Crab -- (the fourth sign of the zodiac; the sun is in this sign from
about June 21 to July 22)
5. Cancer, genus Cancer -- (type genus of the family Cancridae)
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