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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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kwic search for cancer out of >500 occurrences
505522 occurrences (No.25 in the rank) during 5 years in the PubMed. [cache]
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[frequency of next (right) word to cancer]
505522 occurrences (No.25 in the rank) during 5 years in the PubMed. [cache]
| 379) Here, we report that there is an inverse correlation between glutamine metabolic genes and markers of T cell-mediated cytotoxicity in human basal-like breast cancer (BLBC) patient data sets, with increased glutamine metabolism and decreased T cell cytotoxicity associated with poor survival. |
| PMID:33320840 DOI:10.1172/JCI140100 |
| 2021 The Journal of clinical investigation |
| * Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer. |
| - Rapidly proliferating tumor and immune cells need metabolic programs that support energy and biomass production. The amino acid glutamine is consumed by effector T cells and glutamine-addicted triple-negative breast cancer (TNBC) cells, suggesting that a metabolic competition for glutamine may exist within the tumor microenvironment, potentially serving as a therapeutic intervention strategy. Here, we report that there is an inverse correlation between glutamine metabolic genes and markers of T cell-mediated cytotoxicity in human basal-like breast cancer (BLBC) patient data sets, with increased glutamine metabolism and decreased T cell cytotoxicity associated with poor survival. We found that tumor cell-specific loss of glutaminase (GLS), a key enzyme for glutamine metabolism, improved antitumor T cell activation in both a spontaneous mouse TNBC model and orthotopic grafts. The glutamine transporter inhibitor V-9302 selectively blocked glutamine uptake by TNBC cells but not CD8+ T cells, driving synthesis of glutathione, a major cellular antioxidant, to improve CD8+ T cell effector function. We propose a "glutamine steal" scenario, in which cancer cells deprive tumor-infiltrating lymphocytes of needed glutamine, thus impairing antitumor immune responses. Therefore, tumor-selective targeting of glutamine metabolism may be a promising therapeutic strategy in TNBC. |
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| (1)56 *null* | (18)5  elimination |
(35)3 that |
(52)2 does |
| (2)26 and |
(19)5 types |
(36)3 through |
(53)2 genes |
| (3)25 patients |
(20)4 disparities |
(37)3 who |
(54)2 growth |
| (4)21 cells |
(21)4 treatments |
(38)3 with |
(55)2 incidence |
| (5)13 is |
(22)3 (CRC) |
(39)2 (2) |
(56)2 information |
| (6)12 survivors |
(23)3 (HGSOC) |
(40)2 (BC) |
(57)2 medications |
| (7)12 treatment |
(24)3 (SCLC) |
(41)2 (LC) |
(58)2 mental |
| (8)10 pain |
(25)3 SBRT |
(42)2 (NSCLC) |
(59)2 metastasis |
| (9)10 therapy |
(26)3 are |
(43)2 (TNBC) |
(60)2 mice |
| (10)9 cell |
(27)3 diagnosis |
(44)2 ablation |
(61)2 outcomes |
| (11)9 cells, |
(28)3 for |
(45)2 as |
(62)2 prevention, |
| (12)9 in |
(29)3 has |
(46)2 based |
(63)2 recurrence |
| (13)8 risk |
(30)3 immunotherapy |
(47)2 biomarker |
(64)2 subtype-specific |
| (14)7 screening |
(31)3 or |
(48)2 by |
(65)2 survivors, |
| (15)6 cachexia |
(32)3 patient |
(49)2 cardiovascular |
(66)2 throughout |
| (16)6 care |
(33)3 patients, |
(50)2 continuum, |
(67)2 type |
| (17)6 prevention |
(34)3 research |
(51)2 diagnoses |
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--- WordNet output for cancer ---