ELIZA

return kwic search for cancer out of >500 occurrences
505522 occurrences (No.25 in the rank) during 5 years in the PubMed. [cache]

89) In this multicenter prospective cohort study, the usefulness of pre- and posttreatment serum protein levels of potential biomarkers, including squamous cell carcinoma antigen (SCC-Ag), apolipoprotein C-II (ApoC-II), matrix metalloproteinase (MMP)1, and MMP2, were evaluated together with clinical factors in 145 cervical cancer patients in order to determine their suitability to predict survival.

--- ABSTRACT ---

PMID:34727105 DOI:10.1371/journal.pone.0259235

2021 PloS one

* Clinical value of serum biomarkers, squamous cell carcinoma antigen and apolipoprotein C-II in follow-up of patients with locally advanced cervical squamous cell carcinoma treated with radiation: A multicenter prospective cohort study.

- There are currently no reliable, established serum biomarkers to predict the prognosis of radiotherapy for advanced cervical cancer. We aimed to identify serum biomarkers for survival after radiotherapy for cervical cancer. In this multicenter prospective cohort study, the usefulness of pre- and posttreatment serum protein levels of potential biomarkers, including squamous cell carcinoma antigen (SCC-Ag), apolipoprotein C-II (ApoC-II), matrix metalloproteinase (MMP)1, and MMP2, were evaluated together with clinical factors in 145 cervical cancer patients in order to determine their suitability to predict survival. Progression-free survival (PFS) was the primary endpoint, and overall survival (OS), pelvic PFS (PPFS), and distant metastasis-free survival (DMFS) were the secondary endpoints. Blood samples were collected before and 1 month after radiotherapy to measure serum biomarker levels. ApoC-II was measured using a monoclonal antibody-based enzyme-linked immunosorbent assay, which was developed for this purpose. Kaplan-Meier method, log-rank test, and univariate and multivariate Cox proportional hazards models were used for statistical analyses. In multivariate analysis, larger tumor size was independently associated with shorter PFS, OS, PPFS, and DMFS, while longer overall treatment time was independently associated with shorter PPFS. Higher pretreatment SCC-Ag (P < 0.001) was associated with shorter DMFS. Higher posttreatment SCC-Ag (P = 0.017) was also associated with shorter DMFS. Pretreatment ApoC-II was associated with PPFS in univariate analysis (P = 0.048), but not in multivariate analysis. Patients with pretreatment ApoC-II levels ≤ 25.8 μg/ml had shorter PPFS than those with pretreatment ApoC-II levels > 25.8 μg/ml (P = 0.023, log-rank test). Pre- and posttreatment serum SCC-Ag and pretreatment serum ApoC-II levels may be important biomarkers to predict survival outcomes of patients with cervical cancer after radiotherapy. Pre- and posttreatment SCC-Ag and pretreatment ApoC-II might be useful in clinical settings for screening patients to improve treatment strategies in cervical cancer.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to cancer]

(1)56 null	(18)5 elimination	(35)3 that	(52)2 does
(2)26 and	(19)5 types	(36)3 through	(53)2 genes
(3)25 patients	(20)4 disparities	(37)3 who	(54)2 growth
(4)21 cells	(21)4 treatments	(38)3 with	(55)2 incidence
(5)13 is	(22)3 (CRC)	(39)2 (2)	(56)2 information
(6)12 survivors	(23)3 (HGSOC)	(40)2 (BC)	(57)2 medications
(7)12 treatment	(24)3 (SCLC)	(41)2 (LC)	(58)2 mental
(8)10 pain	(25)3 SBRT	(42)2 (NSCLC)	(59)2 metastasis
(9)10 therapy	(26)3 are	(43)2 (TNBC)	(60)2 mice
(10)9 cell	(27)3 diagnosis	(44)2 ablation	(61)2 outcomes
(11)9 cells,	(28)3 for	(45)2 as	(62)2 prevention,
(12)9 in	(29)3 has	(46)2 based	(63)2 recurrence
(13)8 risk	(30)3 immunotherapy	(47)2 biomarker	(64)2 subtype-specific
(14)7 screening	(31)3 or	(48)2 by	(65)2 survivors,
(15)6 cachexia	(32)3 patient	(49)2 cardiovascular	(66)2 throughout
(16)6 care	(33)3 patients,	(50)2 continuum,	(67)2 type
(17)6 prevention	(34)3 research	(51)2 diagnoses

add keyword

--- WordNet output for cancer --- =>【病名】がん, 悪性腫瘍(しゅよう), がん腫, 社会悪, 癌 Overview of noun cancer The noun cancer has 5 senses (first 1 from tagged texts) 1. (15) cancer, malignant neoplastic disease -- (any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream) 2. Cancer, Crab -- ((astrology) a person who is born while the sun is in Cancer) 3. Cancer -- (a small zodiacal constellation in the northern hemisphere; between Leo and Gemini) 4. Cancer, Cancer the Crab, Crab -- (the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22) 5. Cancer, genus Cancer -- (type genus of the family Cancridae) --- WordNet end ---