* Novel acyclic nucleotide analogues GS-343074 and GS-424044 demonstrate antiproliferative and pro-apoptotic activity in canine neoplastic cell lines.
- GS-9219, a novel prodrug of the nucleotide analogue 9-(2-phosphonylmethoxyethyl) guanine (PMEG) has significant activity as monotherapy in dogs with non-Hodgkin's lymphoma. Phase I trials have been initiated in humans based on the encouraging activity observed in canine lymphoma. Two new analogues of GS-9219 (GS-343074 and GS-424044) were recently produced for evaluation as potential novel antineoplastic agents against solid tumours. As a preclinical step, effect of GS-343074 and GS-424044 were evaluated against ten canine cancer cell lines for antiproliferative effect. Both analogues displayed antiproliferative activity against multiple canine cancer cell lines, although GS-343074 was more potent and of broader spectrum compared to GS-424044. Flow cytometric analysis of cells that experienced growth inhibition support apoptotic death as a mechanism of action for both analogues. On the basis of in vitro results described here, GS-343074 and GS-424044 show promise as novel anticancer agents in canine cancer.
=>密室, 細胞, 電池, 独房・細胞, 監房, 組織, 独房
Overview of noun cell
The noun cell has 7 senses (first 3 from tagged texts)
1. (71) cell -- (any small compartment; "the cells of a honeycomb")
2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist
as independent units of life (as in monads) or may form colonies or tissues as in higher plants and
animals)
3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a
chemical reaction)
4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement)
5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile
radiotelephone for use in an area divided into small sections, each with its own short-range
transmitter/receiver)
6. cell, cubicle -- (small room in which a monk or nun lives)
7. cell, jail cell, prison cell -- (a room where a prisoner is kept)
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