ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for cell out of >500 occurrences
928965 occurrences (No.3 in the rank) during 5 years in the PubMed. [no cache] 500 found
25) In the current study, we examined the effects of a small molecule, chloropyramine hydrochloride (C4), designed to disrupt the FAK-VEGFR-3 interaction, upon cellular attachment, migration, and survival in two human neuroblastoma cell lines.
--- ABSTRACT ---
PMID:23868727 DOI:10.1002/mc.22070
2015 Molecular carcinogenesis
* Inhibition of FAK and VEGFR-3 binding decreases tumorigenicity in neuroblastoma.
- Neuroblastoma is the most common extracranial solid tumor of childhood and is responsible for over 15% of pediatric cancer deaths. Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that is important in many facets of tumor development and progression. Vascular endothelial growth factor receptor-3 (VEGFR-3), another tyrosine kinase, has also been found to be important in the development of many human tumors including neuroblastoma. Recent reports have found that FAK and VEGFR-3 interact, and we have previously shown that both of these kinases interact in neuroblastoma. We have hypothesized that interruption of the FAK-VEGFR-3 interaction would lead to decreased neuroblastoma cell survival. In the current study, we examined the effects of a small molecule, chloropyramine hydrochloride (C4), designed to disrupt the FAK-VEGFR-3 interaction, upon cellular attachment, migration, and survival in two human neuroblastoma cell lines. We also utilized a murine xenograft model to study the impact of C4 upon tumor growth. In these studies, we showed that disruption of the FAK-VEGFR-3 interaction led to decreased cellular attachment, migration, and survival in vitro. In addition, treatment of murine xenografts with chloropyramine hydrochloride decreased neuroblastoma xenograft growth. Further, this molecule acted synergistically with standard chemotherapy to further decrease neuroblastoma xenograft growth. The findings from this current study help to further our understanding of the regulation of neuroblastoma tumorigenesis, and may provide novel therapeutic strategies and targets for neuroblastoma and other solid tumors of childhood.
--- ABSTRACT END ---
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[frequency of next (right) word to cell]
(1)30 lines (19)5 tumour (37)3 migration (55)2 lymphoma,
(2)16 death (20)4 (RBC) (38)3 response (56)2 matrices
(3)15 proliferation (21)4 growth (39)3 scaffolds (57)2 numbers
(4)15 viability (22)4 markers (40)3 source (58)2 of
(5)13 lymphoma (23)4 nuclear (41)3 tumors (59)2 printing
(6)12 and (24)4 phenotype (42)3 type (60)2 responses
(7)9 carcinoma (25)4 populations (43)3 viability, (61)2 seeding
(8)9 culture (26)4 therapies (44)2 activation (62)2 survival
(9)9 sheets (27)3 adhesion, (45)2 aggregation (63)2 system
(10)9 transplantation (28)3 division (46)2 attachment (64)2 that
(11)9 types (29)3 energy (47)2 biology (65)2 therapy,
(12)8 adhesion (30)3 expansion (48)2 coating, (66)2 to
(13)8 cycle (31)3 growth, (49)2 death, (67)2 transplantation,
(14)8 therapy (32)3 immunity (50)2 density (68)2 tumours
(15)7 differentiation (33)3 infiltration (51)2 factors (69)2 types,
(16)7 proliferation, (34)3 line, (52)2 genes (70)2 volume
(17)6 surface (35)3 lines, (53)2 interactions (71)2 wall
(18)5 line (36)3 lung (54)2 invasion (72)2 was

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--- WordNet output for cell --- =>密室, 細胞, 電池, 独房・細胞, 監房, 組織, 独房 Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---