ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for cell out of >500 occurrences
928965 occurrences (No.3 in the rank) during 5 years in the PubMed. [cache]
350) Cellular uptake, cell cloning experiments, wound healing assay and cell cycle arrest indicated that the two complexes can inhibit the cell proliferation in SGC-7901 and induce cell cycle arrest at G0/G1 phase.
--- ABSTRACT ---
PMID:34448071 DOI:10.1007/s00775-021-01895-3
2021 Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
* Synthesis and evaluation of iridium(III) complexes on antineoplastic activity against human gastric carcinoma SGC-7901 cells.
- The study was intended to determine the antineoplastic effects of two new iridium(III) complexes [Ir(ppy)2(PTTP)](PF6) (1) (ppy = 2-phenylpyridine) and [Ir(piq)2(PTTP)](PF6) (2) (piq = 1-phenylisoquinoline, PTTP = 2-phenoxy-1,4,8,9-tetraazatriphenylene). In MTT assay, the ligand PTTP displayed ineffective inhibition on cell growth in SGC-7901, BEL-7402, HepG2 as well as NIH3T3 cell lines, while complexes 1 and 2 showed high cytotoxic activity on SGC-7901 cells with an IC50 value of 0.5 ± 0.1 µM and 4.4 ± 0.6 µM, respectively. Cellular uptake, cell cloning experiments, wound healing assay and cell cycle arrest indicated that the two complexes can inhibit the cell proliferation in SGC-7901 and induce cell cycle arrest at G0/G1 phase. Additionally, reactive oxygen species (ROS) and mitochondrial membrane potential suggested that the two complexes induced cell apoptosis through disrupting mitochondrial functions. Further, western blot analysis illustrated that the two complexes caused apoptosis via regulating expression levels of Bcl-2 family proteins. Moreover, complex 1 could suppress tumor growth in vivo with an inhibitory rate of 49.41%. Altogether, these results demonstrated that complexes 1 and 2 exert a potent anticancer effect against SGC-7901 cells via mitochondrial apoptotic pathway and have a potential to be developed as antineoplastic drug candidates for human gastric cancer.
--- ABSTRACT END ---
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[frequency of next (right) word to cell]
(1)23 death (18)5 differentiation (35)3 envelope (52)2 immunity
(2)15 lines (19)5 infiltration (36)3 function (53)2 informative
(3)15 types (20)5 membrane (37)3 growth (54)2 interactions
(4)14 proliferation (21)4 *null* (38)3 lysis (55)2 is
(5)14 wall (22)4 activation (39)3 migration (56)2 killing
(6)8 carcinoma (23)4 apoptosis (40)3 mitochondrial (57)2 malignancies
(7)8 transplantation (24)4 culture (41)3 shape (58)2 manner
(8)7 line (25)4 cultures (42)3 therapy (59)2 marker
(9)7 lung (26)4 invasion (43)2 DNA (60)2 mass
(10)7 populations (27)4 metabolism (44)2 adhesion, (61)2 migration,
(11)7 proliferation, (28)4 receptor (45)2 behavior (62)2 mixture
(12)7 viability (29)4 responses (46)2 biology (63)2 morphology
(13)6 surface (30)4 type (47)2 cholesterol (64)2 nuclear
(14)6 survival (31)3 RNA (48)2 culture, (65)2 number
(15)6 types, (32)3 adhesion (49)2 development (66)2 over-activation,
(16)5 and (33)3 cycle (50)2 fate (67)2 permeability
(17)5 cycle, (34)3 division (51)2 genes

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--- WordNet output for cell --- =>密室, 細胞, 電池, 独房・細胞, 監房, 組織, 独房 Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---