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return kwic search for cell out of >500 occurrences
928965 occurrences (No.3 in the rank) during 5 years in the PubMed. [no cache] 500 found

366) The Akt, family of serine/threonine protein kinases functions as key regulators of multiple aspects of cell behavior, such as survival, proliferation, migration, and carcinogenesis.

--- ABSTRACT ---

PMID:24038446 DOI:10.1002/mc.22075

2015 Molecular carcinogenesis

* Phosphorylation of Smac by Akt promotes the caspase-3 activation during etoposide-induced apoptosis in HeLa cells.

- The Akt, family of serine/threonine protein kinases functions as key regulators of multiple aspects of cell behavior, such as survival, proliferation, migration, and carcinogenesis. Notably, Akt exerts its anti-apoptotic effects through the phosphorylation of numerous substrates related with cell cycle, genome stability, and cancer development. In this report, nevertheless, we focused our view on the novel role of Akt which involves in a pro-apoptotic action by phosphorylating second mitochondria derived activator of caspases (Smac) protein during etoposide-induced apoptotic processes. Our data reveals that Akt could bind to and phosphorylate Smac at serine residue 67, which enhances the ability of Smac to interact with the cytosolic X-chromosome linked IAP (XIAP) protein. The cellular interaction of wild-type Smac with XIAP was enhanced with similar activation kinetics of Akt activity, while this interaction was markedly attenuated in cells expressing the phosphorylation-defective mutant S67A-Smac during etoposide-induced apoptosis. Moreover, we provide the evidence indicating that the phosphorylation of Smac at ser-67 markedly upregulates the caspase-3 activity by promoting the interaction of Smac with XIAP. Taken together, we propose that the phosphorylation of Smac by Akt might be a novel mechanism that involves in amplification of caspase cascade pathway during etoposide-induced apoptosis in HeLa cells.

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[frequency of next (right) word to cell]

(1)30 lines	(19)5 tumour	(37)3 migration	(55)2 lymphoma,
(2)16 death	(20)4 (RBC)	(38)3 response	(56)2 matrices
(3)15 proliferation	(21)4 growth	(39)3 scaffolds	(57)2 numbers
(4)15 viability	(22)4 markers	(40)3 source	(58)2 of
(5)13 lymphoma	(23)4 nuclear	(41)3 tumors	(59)2 printing
(6)12 and	(24)4 phenotype	(42)3 type	(60)2 responses
(7)9 carcinoma	(25)4 populations	(43)3 viability,	(61)2 seeding
(8)9 culture	(26)4 therapies	(44)2 activation	(62)2 survival
(9)9 sheets	(27)3 adhesion,	(45)2 aggregation	(63)2 system
(10)9 transplantation	(28)3 division	(46)2 attachment	(64)2 that
(11)9 types	(29)3 energy	(47)2 biology	(65)2 therapy,
(12)8 adhesion	(30)3 expansion	(48)2 coating,	(66)2 to
(13)8 cycle	(31)3 growth,	(49)2 death,	(67)2 transplantation,
(14)8 therapy	(32)3 immunity	(50)2 density	(68)2 tumours
(15)7 differentiation	(33)3 infiltration	(51)2 factors	(69)2 types,
(16)7 proliferation,	(34)3 line,	(52)2 genes	(70)2 volume
(17)6 surface	(35)3 lines,	(53)2 interactions	(71)2 wall
(18)5 line	(36)3 lung	(54)2 invasion	(72)2 was

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--- WordNet output for cell --- =>密室, 細胞, 電池, 独房・細胞, 監房, 組織, 独房 Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---