ELIZA

return kwic search for cell out of >500 occurrences
928965 occurrences (No.3 in the rank) during 5 years in the PubMed. [cache]

5) Therapeutic implication of PL mediated blockage of NET formation was tested in preclinical model of septic peritonitis, where PL treatment regulated neutrophil cell death modalities including NET formation and mitigated neutrophil mediated inflammatory response.

--- ABSTRACT ---

PMID:34135384 DOI:10.1038/s41598-021-92001-9

2021 Scientific reports

* Helminth derived factors inhibit neutrophil extracellular trap formation and inflammation in bacterial peritonitis.

- Despite their protective antimicrobial function, neutrophil extracellular traps (NETs) have been implicated in propagation of inflammatory responses in several disease conditions including sepsis. Highly diffusible exogenous ROS produced under such inflammatory conditions, can induce exuberant NETs, thus making inhibition of NETs desirable in inflammatory diseases. Here we report that helminth parasite excretory/secretory factors termed as parasitic ligands (PL) inhibit ROS-induced NETs by blocking the activation of nonselective calcium permeable channel Transient Receptor Potential Melastatin 2 (TRPM2). Therapeutic implication of PL mediated blockage of NET formation was tested in preclinical model of septic peritonitis, where PL treatment regulated neutrophil cell death modalities including NET formation and mitigated neutrophil mediated inflammatory response. This translated into improved survival and reduced systemic and local bacterial load in infected mice. Overall, our results posit PL as an important biological regulator of neutrophil functions with implications to a variety of inflammatory diseases including peritonitis.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to cell]

(1)23 death	(18)5 differentiation	(35)3 envelope	(52)2 immunity
(2)15 lines	(19)5 infiltration	(36)3 function	(53)2 informative
(3)15 types	(20)5 membrane	(37)3 growth	(54)2 interactions
(4)14 proliferation	(21)4 null	(38)3 lysis	(55)2 is
(5)14 wall	(22)4 activation	(39)3 migration	(56)2 killing
(6)8 carcinoma	(23)4 apoptosis	(40)3 mitochondrial	(57)2 malignancies
(7)8 transplantation	(24)4 culture	(41)3 shape	(58)2 manner
(8)7 line	(25)4 cultures	(42)3 therapy	(59)2 marker
(9)7 lung	(26)4 invasion	(43)2 DNA	(60)2 mass
(10)7 populations	(27)4 metabolism	(44)2 adhesion,	(61)2 migration,
(11)7 proliferation,	(28)4 receptor	(45)2 behavior	(62)2 mixture
(12)7 viability	(29)4 responses	(46)2 biology	(63)2 morphology
(13)6 surface	(30)4 type	(47)2 cholesterol	(64)2 nuclear
(14)6 survival	(31)3 RNA	(48)2 culture,	(65)2 number
(15)6 types,	(32)3 adhesion	(49)2 development	(66)2 over-activation,
(16)5 and	(33)3 cycle	(50)2 fate	(67)2 permeability
(17)5 cycle,	(34)3 division	(51)2 genes

add keyword

--- WordNet output for cell --- =>密室, 細胞, 電池, 独房・細胞, 監房, 組織, 独房 Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---