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return kwic search for cell out of >500 occurrences
928965 occurrences (No.3 in the rank) during 5 years in the PubMed. [cache]

60) Their combination decreased PDAC cell proliferation and invasion in vitro and suppressed orthotopic tumor growth and liver metastases in vivo.

--- ABSTRACT ---

PMID:33597293 DOI:10.1073/pnas.2012469118

2021 Proceedings of the National Academy of Sciences of the United States of America

* NAD⁺ depletion by type I interferon signaling sensitizes pancreatic cancer cells to NAMPT inhibition.

- Emerging evidence suggests that intratumoral interferon (IFN) signaling can trigger targetable vulnerabilities. A hallmark of pancreatic ductal adenocarcinoma (PDAC) is its extensively reprogrammed metabolic network, in which nicotinamide adenine dinucleotide (NAD) and its reduced form, NADH, are critical cofactors. Here, we show that IFN signaling, present in a subset of PDAC tumors, substantially lowers NAD(H) levels through up-regulating the expression of NAD-consuming enzymes PARP9, PARP10, and PARP14. Their individual contributions to this mechanism in PDAC have not been previously delineated. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD salvage pathway, a dominant source of NAD in cancer cells. We found that IFN-induced NAD consumption increased dependence upon NAMPT for its role in recycling NAM to salvage NAD pools, thus sensitizing PDAC cells to pharmacologic NAMPT inhibition. Their combination decreased PDAC cell proliferation and invasion in vitro and suppressed orthotopic tumor growth and liver metastases in vivo.

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[frequency of next (right) word to cell]

(1)23 death	(18)5 differentiation	(35)3 envelope	(52)2 immunity
(2)15 lines	(19)5 infiltration	(36)3 function	(53)2 informative
(3)15 types	(20)5 membrane	(37)3 growth	(54)2 interactions
(4)14 proliferation	(21)4 null	(38)3 lysis	(55)2 is
(5)14 wall	(22)4 activation	(39)3 migration	(56)2 killing
(6)8 carcinoma	(23)4 apoptosis	(40)3 mitochondrial	(57)2 malignancies
(7)8 transplantation	(24)4 culture	(41)3 shape	(58)2 manner
(8)7 line	(25)4 cultures	(42)3 therapy	(59)2 marker
(9)7 lung	(26)4 invasion	(43)2 DNA	(60)2 mass
(10)7 populations	(27)4 metabolism	(44)2 adhesion,	(61)2 migration,
(11)7 proliferation,	(28)4 receptor	(45)2 behavior	(62)2 mixture
(12)7 viability	(29)4 responses	(46)2 biology	(63)2 morphology
(13)6 surface	(30)4 type	(47)2 cholesterol	(64)2 nuclear
(14)6 survival	(31)3 RNA	(48)2 culture,	(65)2 number
(15)6 types,	(32)3 adhesion	(49)2 development	(66)2 over-activation,
(16)5 and	(33)3 cycle	(50)2 fate	(67)2 permeability
(17)5 cycle,	(34)3 division	(51)2 genes

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--- WordNet output for cell --- =>密室, 細胞, 電池, 独房・細胞, 監房, 組織, 独房 Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---