ELIZA

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856246 occurrences (No.4 in the rank) during 5 years in the PubMed. [cache]

234) An active infection of epithelial cells with RSV in vitro results in heightened central metabolism and overall hypermetabolic state; however, little is known about whether natural infection with RSV in vivo results in lasting metabolic reprogramming of the airway epithelium in infancy.

--- ABSTRACT ---

PMID:34696488 DOI:10.3390/v13102055

2021 Viruses

* Metabolic Reprogramming of Nasal Airway Epithelial Cells Following Infant Respiratory Syncytial Virus Infection.

- Respiratory syncytial virus (RSV) is a seasonal mucosal pathogen that infects the ciliated respiratory epithelium and results in the most severe morbidity in the first six months of life. RSV is a common cause of acute respiratory infection during infancy and is an important early-life risk factor strongly associated with asthma development. While this association has been repeatedly demonstrated, limited progress has been made on the mechanistic understanding in humans of the contribution of infant RSV infection to airway epithelial dysfunction. An active infection of epithelial cells with RSV in vitro results in heightened central metabolism and overall hypermetabolic state; however, little is known about whether natural infection with RSV in vivo results in lasting metabolic reprogramming of the airway epithelium in infancy. To address this gap, we performed functional metabolomics, 13C glucose metabolic flux analysis, and RNA-seq gene expression analysis of nasal airway epithelial cells (NAECs) sampled from infants between 2-3 years of age, with RSV infection or not during the first year of life. We found that RSV infection in infancy was associated with lasting epithelial metabolic reprogramming, which was characterized by (1) significant increase in glucose uptake and differential utilization of glucose by epithelium; (2) altered preferences for metabolism of several carbon and energy sources; and (3) significant sexual dimorphism in metabolic parameters, with RSV-induced metabolic changes most pronounced in male epithelium. In summary, our study supports the proposed phenomenon of metabolic reprogramming of epithelial cells associated with RSV infection in infancy and opens exciting new venues for pursuing mechanisms of RSV-induced epithelial barrier dysfunction in early life.

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[frequency of next (right) word to cells]

(1)86 null	(13)6 we	(25)3 during	(37)2 into
(2)61 and	(14)5 can	(26)3 have	(38)2 leads
(3)24 in	(15)5 is	(27)3 may	(39)2 regardless
(4)18 to	(16)5 treated	(28)3 using	(40)2 respectively
(5)13 are	(17)4 or	(29)2 (HBECs)	(41)2 show
(6)10 from	(18)4 revealed	(30)2 (HSCs)	(42)2 showed
(7)10 that	(19)4 was	(31)2 (OHCs)	(43)2 suggesting
(8)9 were	(20)4 while	(32)2 (PBMCs)	(44)2 supporting
(9)8 with	(21)3 (MSCs)	(33)2 at	(45)2 via
(10)7 of	(22)3 but	(34)2 could
(11)6 as	(23)3 by	(35)2 differentiate
(12)6 for	(24)3 derived	(36)2 including

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--- WordNet output for cells --- Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---