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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for cells out of >500 occurrences
856246 occurrences (No.4 in the rank) during 5 years in the PubMed. [no cache] 500 found
28) Furthermore, bufalin markedly inhibited MMP-2 and -9 activity, mRNA expression and protein levels in SK-Hep1 cells.
--- ABSTRACT ---
PMID:23949904 DOI:10.1002/tox.21896
2015 Environmental toxicology
* Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and matrix metalloproteinase-2/-9-signaling pathways.
- Metastasis plays an important role in mortality of cancer patients. Migration and invasion are the major characteristics of tumor metastasis. The induction of matrix metalloproteinases (MMPs) such as MMP-2 and -9 are particularly important for the invasiveness of various cancer cells. Bufalin, a class of toxic steroids, was purified from the skin glands of Bufo gargarizans or Bufo melanostictus; it is known to inhibit proliferation of human cancer cells. In this study, we investigated the antiinvasive mechanisms of bufalin in the human hepatocellular cancer cell line SK-Hep1. Bufalin significantly reduced serum-induced cell invasion and migration. Furthermore, bufalin markedly inhibited MMP-2 and -9 activity, mRNA expression and protein levels in SK-Hep1 cells. Bufalin attenuated phosphoinisitide-3-kinase (PI3K) and phosphorylation of AKT which was associated with reduced levels of nuclear factor kappa B (NF-κB). Bufalin also suppressed protein levels of FAK and Rho A, VEGF, MEKK3, MKK7, and uPA and it diminished NF-κB translocation. Based on these observations, we propose that bufalin is acts as an antiinvasive agent by inhibiting MMP-2 and -9 and involving PI3K/AKT and NF-κB pathways. Bufalin is a potential therapeutic agent that may have efficacy in preventing the invasion and metastasis of malignant liver tumors.
--- ABSTRACT END ---
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[frequency of next (right) word to cells]
(1)80 *null* (15)5 as (29)3 exposed (43)2 expanded
(2)47 and (16)5 expressed (30)3 have (44)2 expressing
(3)39 were (17)5 of (31)3 isolated (45)2 had
(4)26 in (18)5 which (32)3 showed (46)2 labeled
(5)12 (MSCs) (19)4 (ASCs) (33)3 we (47)2 may
(6)11 was (20)4 has (34)2 (ASCs), (48)2 play
(7)10 to (21)4 is (35)2 (BMSCs) (49)2 present
(8)9 with (22)4 on (36)2 (ECFCs) (50)2 remains
(9)7 are (23)4 seeded (37)2 (HSCs) (51)2 such
(10)6 can (24)4 within (38)2 after (52)2 the
(11)6 for (25)3 (ASC) (39)2 by (53)2 via
(12)6 from (26)3 (ECs) (40)2 caused
(13)6 or (27)3 (HUVECs) (41)2 cultured
(14)6 that (28)3 (hMSCs) (42)2 derived

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--- WordNet output for cells --- Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---