ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for cells out of >500 occurrences
856246 occurrences (No.4 in the rank) during 5 years in the PubMed. [cache]
339) Disturbance in a differentiation program of skeletal stem cells leads to indecorous skeletogenesis.
--- ABSTRACT ---
PMID:34638628 DOI:10.3390/ijms221910289
2021 International journal of molecular sciences
* Deubiquitinating Enzyme USP8 Is Essential for Skeletogenesis by Regulating Wnt Signaling.
- Disturbance in a differentiation program of skeletal stem cells leads to indecorous skeletogenesis. Growing evidence suggests that a fine-tuning of ubiquitin-mediated protein degradation is crucial for skeletal stem cells to maintain their stemness and osteogenic potential. Here, we demonstrate that the deubiquitinating enzyme (DUB) ubiquitin-specific protease 8 (USP8) stabilizes the Wnt receptor frizzled 5 (FZD5) by preventing its lysosomal degradation. This pathway is essential for Wnt/β-catenin signaling and the differentiation of osteoprogenitors to mature osteoblasts. Accordingly, deletion of USP8 in osteoprogenitors (Usp8Osx) resulted in a near-complete blockade in skeletal mineralization, similar to that seen in mice with defective Wnt/β-catenin signaling. Likewise, transplanting USP8-deficient osteoprogenitors under the renal capsule in wild-type secondary hosts did not to induce bone formation. Collectively, this study unveils an essential role for the DUB USP8 in Wnt/β-catenin signaling in osteoprogenitors and osteogenesis during skeletal development.
--- ABSTRACT END ---
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[frequency of next (right) word to cells]
(1)86 *null* (13)6 we (25)3 during (37)2 into
(2)61 and (14)5 can (26)3 have (38)2 leads
(3)24 in (15)5 is (27)3 may (39)2 regardless
(4)18 to (16)5 treated (28)3 using (40)2 respectively
(5)13 are (17)4 or (29)2 (HBECs) (41)2 show
(6)10 from (18)4 revealed (30)2 (HSCs) (42)2 showed
(7)10 that (19)4 was (31)2 (OHCs) (43)2 suggesting
(8)9 were (20)4 while (32)2 (PBMCs) (44)2 supporting
(9)8 with (21)3 (MSCs) (33)2 at (45)2 via
(10)7 of (22)3 but (34)2 could
(11)6 as (23)3 by (35)2 differentiate
(12)6 for (24)3 derived (36)2 including

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--- WordNet output for cells --- Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---