ELIZA

return kwic search for cells out of >500 occurrences
856246 occurrences (No.4 in the rank) during 5 years in the PubMed. [cache]

360) Elevated aldehyde dehydrogenase (ALDH) activity correlates with poor outcome for many solid tumors as ALDHs may regulate cell proliferation and chemoresistance of cancer stem cells (CSCs).

--- ABSTRACT ---

PMID:34934174 DOI:10.1038/s42003-021-02949-7

2021 Communications biology

* A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells.

- Elevated aldehyde dehydrogenase (ALDH) activity correlates with poor outcome for many solid tumors as ALDHs may regulate cell proliferation and chemoresistance of cancer stem cells (CSCs). Accordingly, potent, and selective inhibitors of key ALDH enzymes may represent a novel CSC-directed treatment paradigm for ALDH⁺ cancer types. Of the many ALDH isoforms, we and others have implicated the elevated expression of ALDH1A3 in mesenchymal glioma stem cells (MES GSCs) as a target for the development of novel therapeutics. To this end, our structure of human ALDH1A3 combined with in silico modeling identifies a selective, active-site inhibitor of ALDH1A3. The lead compound, MCI-INI-3, is a selective competitive inhibitor of human ALDH1A3 and shows poor inhibitory effect on the structurally related isoform ALDH1A1. Mass spectrometry-based cellular thermal shift analysis reveals that ALDH1A3 is the primary binding protein for MCI-INI-3 in MES GSC lysates. The inhibitory effect of MCI-INI-3 on retinoic acid biosynthesis is comparable with that of ALDH1A3 knockout, suggesting that effective inhibition of ALDH1A3 is achieved with MCI-INI-3. Further development is warranted to characterize the role of ALDH1A3 and retinoic acid biosynthesis in glioma stem cell growth and differentiation.

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(1)86 null	(13)6 we	(25)3 during	(37)2 into
(2)61 and	(14)5 can	(26)3 have	(38)2 leads
(3)24 in	(15)5 is	(27)3 may	(39)2 regardless
(4)18 to	(16)5 treated	(28)3 using	(40)2 respectively
(5)13 are	(17)4 or	(29)2 (HBECs)	(41)2 show
(6)10 from	(18)4 revealed	(30)2 (HSCs)	(42)2 showed
(7)10 that	(19)4 was	(31)2 (OHCs)	(43)2 suggesting
(8)9 were	(20)4 while	(32)2 (PBMCs)	(44)2 supporting
(9)8 with	(21)3 (MSCs)	(33)2 at	(45)2 via
(10)7 of	(22)3 but	(34)2 could
(11)6 as	(23)3 by	(35)2 differentiate
(12)6 for	(24)3 derived	(36)2 including

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--- WordNet output for cells --- Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---