ELIZA

return kwic search for changes out of >500 occurrences
332920 occurrences (No.57 in the rank) during 5 years in the PubMed. [no cache] 500 found

447) CRS induced ulcerogenesis was associated with reductions in levels of brain and plasma NOx and GSH levels while MDA levels were elevated in both male and female rats- the magnitude of these changes being higher in males than in females.

--- ABSTRACT ---

PMID:23782143 DOI:10.1111/jpc.12302

2015 Current pharmaceutical design

* Gender Based Differences in Stress-induced Gastric Ulcer Formation and its Regulation by Nitric Oxide (NO): An Experimental Study.

- A variety of physiological and pharmacological factors are known to influence stress responses. Cold restraint stress (CRS) induced gastric ulcerogenesis in both the sexes but such ulceration was found to be markedly higher in male than in female rats. In males, CRS induced significant increases in both ulcer number and ulcer severity; while the females though showed a trend towards increase in both the parameters, the extent of changes was far less than in males. Pre-administration of the NO mimetic, L-Arginine (500 and 1000 mg/kg), prior to CRS, dose dependently decreased ulcer number and severity in male rats. In female rats, L-Arginine also induced a gastric cytoprotective effect during CRS but to a much lesser extent. On the other hand, inhibition of NO synthesis by LNAME (25 and 50 mg/kg) further aggravated such stress ulcerogensis in both males and females, with aggravations being more extensive in males. CRS induced ulcerogenesis was associated with reductions in levels of brain and plasma NOx and GSH levels while MDA levels were elevated in both male and female rats- the magnitude of these changes being higher in males than in females. In female rats, pretreatment with formestane (aromatase inhibitor) but not tamoxifen (estrogen receptor blocker) aggravated stress ulcer formation as compared to vehicle treated CRS exposed rats. Formestane pretreatment also induced greater suppressions in brain NOx and GSH and elevations in brain MDA, as compared to vehicle treated CRS rats. These results indicate that estrogen and its interactions with oxidative stress markers and NO plays a key role in the gender based differences in stress induced gastric ulcerogenesis. It may be speculated that, in males, CRS induces greater reductions in brain NO and enhancement in oxidative injury resulting in greater severity of gastric ulceration. On the other hand, greater resistance of females to ulcerogenic effects of CRS may be due to the protection conferred by estrogen and this effect seems to be related to interactions with brain NO.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to changes]

(1)247 in	(8)8 that	(15)3 have	(22)2 for
(2)31 of	(9)7 during	(16)3 over	(23)2 induced
(3)26 null	(10)6 may	(17)3 the	(24)2 or
(4)26 were	(11)5 at	(18)3 was	(25)2 related
(5)15 to	(12)4 on	(19)2 accompany	(26)2 seen
(6)13 and	(13)3 as	(20)2 can	(27)2 such
(7)8 are	(14)3 by	(21)2 could	(28)2 which

add keyword

--- WordNet output for changes --- Overview of noun change The noun change has 10 senses (first 7 from tagged texts) 1. (46) change, alteration, modification -- (an event that occurs when something passes from one state or phase to another; "the change was intended to increase sales"; "this storm is certainly a change for the worse"; "the neighborhood had undergone few modifications since his last visit years ago") 2. (45) change -- (a relational difference between states; especially between states before and after some event; "he attributed the change to their marriage") 3. (17) change -- (the action of changing something; "the change of government had no impact on the economy"; "his change on abortion cost him the election") 4. (13) change -- (the result of alteration or modification; "there were marked changes in the lining of the lungs"; "there had been no change in the mountains") 5. (2) change -- (the balance of money received when the amount you tender is greater than the amount due; "I paid with a twenty and pocketed the change") 6. (1) change -- (a thing that is different; "he inspected several changes before selecting one") 7. (1) change -- (a different or fresh set of clothes; "she brought a change in her overnight bag") 8. change -- (coins of small denomination regarded collectively; "he had a pocketful of change") 9. change -- (money received in return for its equivalent in a larger denomination or a different currency; "he got change for a twenty and used it to pay the taxi driver") 10. variety, change -- (a difference that is usually pleasant; "he goes to France for variety"; "it is a refreshing change to meet a woman mechanic") Overview of verb change The verb change has 10 senses (first 8 from tagged texts) 1. (57) change, alter, modify -- (cause to change; make different; cause a transformation; "The advent of the automobile may have altered the growth pattern of the city"; "The discussion has changed my thinking about the issue") 2. (54) change -- (undergo a change; become different in essence; losing one's or its original nature; "She changed completely as she grew older"; "The weather changed last night") 3. (13) change, alter, vary -- (become different in some particular way, without permanently losing one's or its former characteristics or essence; "her mood changes in accordance with the weather"; "The supermarket's selection of vegetables varies according to the season") 4. (7) switch, shift, change -- (lay aside, abandon, or leave for another; "switch to a different brand of beer"; "She switched psychiatrists"; "The car changed lanes") 5. (6) change -- (change clothes; put on different clothes; "Change before you go to the opera") 6. (5) change, exchange, commute, convert -- (exchange or replace with another, usually of the same kind or category; "Could you convert my dollars into pounds?"; "He changed his name"; "convert centimeters into inches"; "convert holdings into shares") 7. (3) exchange, change, interchange -- (give to, and receive from, one another; "Would you change places with me?"; "We have been exchanging letters for a year") 8. (3) transfer, change -- (change from one vehicle or transportation line to another; "She changed in Chicago on her way to the East coast") 9. deepen, change -- (become deeper in tone; "His voice began to change when he was 12 years old"; "Her voice deepened when she whispered the password") 10. change -- (remove or replace the coverings of; "Father had to learn how to change the baby"; "After each guest we changed the bed linens") --- WordNet end ---