ELIZA

return kwic search for clinical out of >500 occurrences
554339 occurrences (No.20 in the rank) during 5 years in the PubMed. [no cache] 500 found

139) Building on the introductory paper of this Series, this paper discusses data-driven approaches to clinical trial research across several adaptive trial designs, as well as the master protocol framework that can help to harmonise clinical trial research efforts in global health research.

--- ABSTRACT ---

PMID:33865474 DOI:10.1016/S2214-109X(20)30540-4

2021 The Lancet. Global health

* Randomised trials at the level of the individual.

- In global health research, short-term, small-scale clinical trials with fixed, two-arm trial designs that generally do not allow for major changes throughout the trial are the most common study design. Building on the introductory paper of this Series, this paper discusses data-driven approaches to clinical trial research across several adaptive trial designs, as well as the master protocol framework that can help to harmonise clinical trial research efforts in global health research. We provide a general framework for more efficient trial research, and we discuss the importance of considering different study designs in the planning stage with statistical simulations. We conclude this second Series paper by discussing the methodological and operational complexity of adaptive trial designs and master protocols and the current funding challenges that could limit uptake of these approaches in global health research.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to clinical]

(1)48 trials	(20)4 phenotypes	(39)3 severity,	(58)2 examination
(2)29 and	(21)4 setting	(40)3 social	(59)2 experience
(3)28 studies	(22)4 treatment	(41)3 trials,	(60)2 genetics
(4)24 practice	(23)3 Trial	(42)3 use	(61)2 guidelines
(5)18 trial	(24)3 Trials	(43)3 variables,	(62)2 manifestations
(6)15 outcomes	(25)3 application	(44)2 PGx	(63)2 manifestations,
(7)9 data	(26)3 applications,	(45)2 Trials,	(64)2 needs
(8)7 settings	(27)3 characteristics,	(46)2 applicability	(65)2 oncology
(9)7 signs	(28)3 conditions	(47)2 assessments	(66)2 parameters
(10)7 utility	(29)3 data,	(48)2 benefits	(67)2 research
(11)5 impact	(30)3 decision	(49)2 case	(68)2 services
(12)5 relevance	(31)3 effectiveness	(50)2 checklist	(69)2 settings,
(13)5 studies,	(32)3 evidence	(51)2 conversations	(70)2 specimens
(14)4 care	(33)3 factors	(52)2 correlates	(71)2 survey
(15)4 diagnosis	(34)3 features	(53)2 courses	(72)2 syndrome
(16)4 efficacy	(35)3 health	(54)2 decision-making	(73)2 trial,
(17)4 levels	(36)3 isolates	(55)2 dental	(74)2 validity
(18)4 or	(37)3 outcomes,	(56)2 disease
(19)4 outcome	(38)3 populations	(57)2 epidemiology

add keyword

--- WordNet output for clinical --- =>客観的な態度の, 臨床の, 臨床治療の, 臨床, 分析的な, 冷静な, 客観的な, 病院に関するものだ, 病院関係の Overview of adj clinical The adj clinical has 2 senses (first 2 from tagged texts) 1. (14) clinical -- (relating to a clinic or conducted in or as if in a clinic and depending on direct observation of patients; "clinical observation"; "clinical case study") 2. (1) clinical -- (scientifically detached; unemotional; "he spoke in the clipped clinical monotones typical of police testimony") --- WordNet end ---