285) The study aimed to evaluate the possible contribution of CTLA-4 exon 1 49 A>G polymorphism to the pathogenesis of ITP and its relation to age of disease onset, clinical course, and response to therapy. |
PMID:24023266 DOI:10.1177/1076029613502254 |
2015 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis |
* Lack of impact of cytotoxic T-lymphocyte antigen 4 gene exon 1 polymorphism on susceptibility to or clinical course of egyptian childhood immune thrombocytopenic purpura. |
- Dysfunctional T-lymphocyte immunity plays an important role in the pathophysiology of immune thrombocytopenic purpura (ITP). Cytotoxic T-lymphocyte antigen 4 (CTLA-4)-a surface marker expressed on T regulatory cells and activated T lymphocytes-is a negative modulator of T-cell responses. Polymorphisms of the CTLA-4 may alter the level of antigen expression and hence may influence immune regulation. The study aimed to evaluate the possible contribution of CTLA-4 exon 1 49 AThe study aimed to evaluate the possible contribution of CTLA-4 exon 1 49 A>G polymorphism to the pathogenesis of ITP and its relation to age of disease onset, clinical course, and response to therapy.gt;G polymorphism to the pathogenesis of ITP and its relation to age of disease onset, clinical course, and response to therapy. Genotyping of CTLA-4 exon 1 49 A>G was performed in 100 pediatric patients with ITP and 259 healthy individuals by polymerase chain reaction-restricted fragment length polymorphism. No significant differences existed in genotype or allele distributions between patients and controls for the studied polymorphism. Comparable genotypes and allele frequencies were obtained between the 2 groups after their stratification by age of disease onset, clinical course, or response to therapy. In conclusion, CTLA-4 exon 1 49 A>G polymorphism is not associated with susceptibility to ITP in the Egyptian population; neither it affects the clinical picture of the disease. |
(1)36 and | (17)5 application | (33)3 attachment | (49)2 grading |
(2)26 practice | (18)5 data | (34)3 course, | (50)2 interventions |
(3)22 trials | (19)5 efficacy | (35)3 examination, | (51)2 literature |
(4)19 trial | (20)5 features | (36)3 experience | (52)2 measures |
(5)14 research | (21)5 outcome | (37)3 information | (53)2 nurse |
(6)14 studies | (22)5 picture | (38)3 manifestations | (54)2 observations |
(7)10 use | (23)5 relevance | (39)3 significance | (55)2 point |
(8)8 parameters | (24)5 symptoms | (40)3 variables | (56)2 practice, |
(9)8 settings | (25)5 translation | (41)2 benefits | (57)2 presentation, |
(10)8 signs | (26)5 trials, | (42)2 cases | (58)2 process |
(11)8 study | (27)5 utility | (43)2 conditions | (59)2 results |
(12)7 examination | (28)4 characteristics | (44)2 context | (60)2 sample, |
(13)7 implications | (29)4 evaluation | (45)2 decision-making | (61)2 situation |
(14)7 presentation | (30)4 management | (46)2 decisions | (62)2 situations, |
(15)6 applications | (31)4 outcomes | (47)2 diagnosis | (63)2 success |
(16)6 course | (32)4 signs, | (48)2 findings | (64)2 tooth |
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