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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
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270181 occurrences (No.97 in the rank) during 5 years in the PubMed. [cache]
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270181 occurrences (No.97 in the rank) during 5 years in the PubMed. [cache]
| 218) Compared to controls, spinal cords from rodents treated with nanoparticle site-directed estrogen demonstrated significantly decreased post-injury lesion size, reactive gliosis, and glial scar formation. |
| PMID:32680442 DOI:10.1089/neu.2020.7047 |
| 2021 Journal of neurotrauma |
| * Nanoparticle-Based Estrogen Delivery to Spinal Cord Injury Site Reduces Local Parenchymal Destruction and Improves Functional Recovery. |
| - Spinal cord injury (SCI) patients sustain significant functional impairments; this is causally related to restricted neuronal regeneration after injury. The ensuing reactive gliosis, inflammatory cascade, and glial scar formation impede axonal regrowth. Although systemic anti-inflammatory agents (steroids) have been previously administered to counteract this, no current therapeutic is approved for post-injury neuronal regeneration, in part because of related side effects. Likewise, therapeutic systemic estrogen levels exhibit neuroprotective properties, but dose-dependent side effects are prohibitive. The current study thus uses low-dose estrogen delivery to the spinal cord injury (SCI) site using an agarose gel patch embedded with estrogen-loaded nanoparticles. Compared to controls, spinal cords from rodents treated with nanoparticle site-directed estrogen demonstrated significantly decreased post-injury lesion size, reactive gliosis, and glial scar formation. However, axonal regeneration, vascular endothelial growth factor production, and glial-cell-derived neurotrophic factor levels were increased with estrogen administration. Concomitantly improved locomotor and bladder functional recovery were observed with estrogen administration after injury. Therefore, low-dose site-directed estrogen may provide a future approach for enhanced neuronal repair and functional recovery in SCI patients. |
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(17)4 standard |
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(18)4 women |
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(21)3 no |
(34)2 any |
(47)2 uninfected |
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(22)3 non-obese |
(35)2 children |
(48)2 untreated |
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(23)3 wild-type |
(36)2 expert |
(49)2 usual |
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(24)2 B-385 |
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(26)2 CS- |
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--- WordNet output for compared ---