ELIZA

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291) The data indicate that epigenetic mechanisms induced by early adverse environment memorize life experience to trigger greater opiate vulnerability during adult life.

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PMID:23980619 DOI:10.1111/adb.12084

2015 Addiction biology

* Vulnerability to opiate intake in maternally deprived rats: implication of MeCP2 and of histone acetylation.

- We previously showed that maternal deprivation predisposes male rats to anxiety, accompanied with an increase in their opiate consumption. In the present report, we searched for brain epigenetic mechanisms that possibly underlie this increase. For that, we examined the expression of the methyl-CpG-binding protein MeCP2 and of the histone deacetylases HDAC2 and HDAC3, as well as the acetylation status of histone H3 and H4 in mesolimbic structures of adult maternally deprived rats, using immunohistochemistry and Western blot analysis. A long-lasting increase in MeCP2 expression was found throughout the striatum of deprived rats. Enhanced HDAC2 expression and increased nuclear HDAC activity in the nucleus accumbens of deprived rats were associated with lower acetylation levels of histone H3 and H4. Treatment for 3 weeks with the HDAC inhibitor sodium valproate abolished HDAC activation together with the decrease in the acetylation levels of histone H4, and was accompanied with normalized oral morphine consumption. The data indicate that epigenetic mechanisms induced by early adverse environment memorize life experience to trigger greater opiate vulnerability during adult life. They suggest that sodium valproate may lessen vulnerability to opiate intake, particularly in subgroups of individuals subjected to adverse postnatal environments.

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(2)55 were	(15)7 support	(28)3 can	(41)2 by
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(4)26 on	(17)6 analysis	(30)3 in	(43)2 clustering
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(7)17 suggest	(20)5 sets	(33)3 the	(46)2 highlight
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(10)11 to	(23)4 demonstrate	(36)3 would	(49)2 shows
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(13)7 indicate	(26)4 regarding	(39)2 as

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--- WordNet output for data --- =>データ, 資料 Overview of noun data The noun data has 1 sense (first 1 from tagged texts) 1. (76) data, information -- (a collection of facts from which conclusions may be drawn; "statistical data") Overview of noun datum The noun datum has 1 sense (first 1 from tagged texts) 1. (5) datum, data point -- (an item of factual information derived from measurement or research) --- WordNet end ---