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return kwic search for demonstrated out of >500 occurrences
286534 occurrences (No.87 in the rank) during 5 years in the PubMed. [cache]

164) We also demonstrated that tumour-derived exosomes promoted tumour cell migration, but not proliferation and apoptosis.

--- ABSTRACT ---

PMID:34468926 DOI:10.1007/s11010-021-04254-7

2021 Molecular and cellular biochemistry

* Serum exosome-derived biomarkers for the early detection of oral squamous cell carcinoma.

- Blood exosomes help regulate communication between tumour cells, moderating their behaviour. We sought to determine the protein content in serum exosomes (SEs), to characterise SEs, and to discover novel clinical biomarkers of oral squamous cell carcinoma (OSCC). Differentially expressed proteins (DEPs) of OSCC were identified using proteomics and then analysed using bioinformatics, before validation using ELISA, IHC, and RT-PCR. The influence of SEs on oral cancer cells was detected using CCK-8 and migration assays. Twelve DEPs were found in SEs from OSCC. Four proteins were targeted for further verification. New biomarkers exhibiting high sensitivity and specificity in diagnosing OSCC comprised C-reactive protein (CRP), von willebrand factor (VWF), and leucine-rich alpha-2-glycoprotein (LRG). Combined biomarkers outperformed any single protein. We also demonstrated that tumour-derived exosomes promoted tumour cell migration, but not proliferation and apoptosis. Our study indicates that CRP, VWF, and LRG are potential clinically relevant OSCC biomarkers. OSCC-related SEs may help promote migration of oral cells.

--- ABSTRACT END ---

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[frequency of next (right) word to demonstrated]

(1)169 that	(11)5 good	(21)3 that,	(31)2 leadership
(2)48 a	(12)5 using	(22)2 altered	(32)2 on
(3)34 the	(13)5 with	(23)2 benefits	(33)2 positive
(4)18 in	(14)4 comparable	(24)2 decreases	(34)2 potential
(5)17 to	(15)4 for	(25)2 elevated	(35)2 robustness
(6)16 by	(16)4 how	(26)2 evidence	(36)2 significantly
(7)9 an	(17)4 its	(27)2 greater	(37)2 similar
(8)8 significant	(18)3 improved	(28)2 higher	(38)2 statistically
(9)7 null	(19)3 no	(29)2 highly	(39)2 successful
(10)7 efficacy	(20)3 several	(30)2 increased	(40)2 survival

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--- WordNet output for demonstrated --- Overview of verb demonstrate The verb demonstrate has 4 senses (first 4 from tagged texts) 1. (24) show, demo, exhibit, present, demonstrate -- (give an exhibition of to an interested audience; "She shows her dogs frequently"; "We will demo the new software in Washington") 2. (22) prove, demonstrate, establish, show, shew -- (establish the validity of something, as by an example, explanation or experiment; "The experiment demonstrated the instability of the compound"; "The mathematician showed the validity of the conjecture") 3. (2) attest, certify, manifest, demonstrate, evidence -- (provide evidence for; stand as proof of; show by one's behavior, attitude, or external attributes; "His high fever attested to his illness"; "The buildings in Rome manifest a high level of architectural sophistication"; "This decision demonstrates his sense of fairness") 4. (1) demonstrate, march -- (march in protest; take part in a demonstration; "Thousands demonstrated against globalization during the meeting of the most powerful economic nations in Seattle") Overview of adj demonstrated The adj demonstrated has 1 sense (first 1 from tagged texts) 1. (1) demonstrated -- (having been demonstrated or verified beyond doubt) --- WordNet end ---