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286534 occurrences (No.87 in the rank) during 5 years in the PubMed. [no cache] 500 found

423) We demonstrated associations of life events experienced during the last year: negative life events were positively associated with cortisol-responses in the challenge paradigm (β=0.28, p<0.05), while positive life events were inversely associated (β=-0.29, p<0.05).

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PMID:24374553 DOI:10.1016/j.bbr.2013.12.023

2015 Behavioural brain research

* Variations in central serotonergic activity - relevance of the 5-HTTLPR, life events and their interaction.

- The 5-HTTLPR and its interaction with adverse life events has been studied widely; especially with regard to depression. Few studies are available relating the respective association with acute serotonergic functionality. We examined the effects of the 5-HTTLPR, life events and their interaction on serotonergic responsivity using S-citalopram (10mg) in a placebo-controlled double-blind neuroendocrine challenge paradigm (n=59 healthy males). We considered positive and negative life events, life events experienced during the last year and accumulated over the whole life span and possible mediating effects of neuroticism, extraversion and openness to experience. We demonstrated associations of life events experienced during the last year: negative life events were positively associated with cortisol-responses in the challenge paradigm (β=0.28, p<0.05), while positive life events were inversely associated (β=-0.29, p<0.05). Neither the main effect of 5-HTTLPR-genotype nor its interactions with life events predicted the acute serotonergic functionality. In addition, openness for feelings significantly predicted the serotonergic responsivity, while no other personality traits measured in this study mediated the effect of life events. Our results question not only the stability of serotonergic activity but, importantly, add to the literature concerning the serotonergic system as a general threshold modulating system, i.e. being associated with the processing of positive as well as negative stimuli.

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[frequency of next (right) word to demonstrated]

(1)158 that	(10)5 good	(19)3 excellent	(28)2 efficacy
(2)48 the	(11)5 increased	(20)3 more	(29)2 greater
(3)40 a	(12)5 significantly	(21)3 no	(30)2 how
(4)23 by	(13)4 as	(22)3 that,	(31)2 successful
(5)21 to	(14)4 better	(23)2 acceptable	(32)2 through
(6)13 in	(15)4 improved	(24)2 and	(33)2 using
(7)12 null	(16)4 its	(25)2 both
(8)11 an	(17)4 similar	(26)2 decreased
(9)8 for	(18)3 between	(27)2 differential

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--- WordNet output for demonstrated --- Overview of verb demonstrate The verb demonstrate has 4 senses (first 4 from tagged texts) 1. (24) show, demo, exhibit, present, demonstrate -- (give an exhibition of to an interested audience; "She shows her dogs frequently"; "We will demo the new software in Washington") 2. (22) prove, demonstrate, establish, show, shew -- (establish the validity of something, as by an example, explanation or experiment; "The experiment demonstrated the instability of the compound"; "The mathematician showed the validity of the conjecture") 3. (2) attest, certify, manifest, demonstrate, evidence -- (provide evidence for; stand as proof of; show by one's behavior, attitude, or external attributes; "His high fever attested to his illness"; "The buildings in Rome manifest a high level of architectural sophistication"; "This decision demonstrates his sense of fairness") 4. (1) demonstrate, march -- (march in protest; take part in a demonstration; "Thousands demonstrated against globalization during the meeting of the most powerful economic nations in Seattle") Overview of adj demonstrated The adj demonstrated has 1 sense (first 1 from tagged texts) 1. (1) demonstrated -- (having been demonstrated or verified beyond doubt) --- WordNet end ---