* Optimization of carboxylate-terminated poly(amidoamine) dendrimer-mediated cisplatin formulation.
- Abstract Cisplatin is mainly used in the treatment of ovarian, head and neck and testicular cancer. Poor solubility and non-specific interactions causes hurdles in the development of successful cisplatin formulation. There were few reports on poly(amidoamine) (PAMAM) dendrimer-cisplatin complexes for anticancer treatment. But the earlier research was mainly focused on therapeutic effect of PAMAM dendrimer-cisplatin complex, with less attention paid on the formulation development of these complexes. Objective of the present study is to optimize and validate the carboxylate-terminated, EDA core PAMAM dendrimer-based cisplatin formulation with respect to various variables such as dendrimer core, generation, drug entrapment, purification, yield, reproducibility, stability, storage and in-vitro release. Dendrimer-cisplatin complex was prepared by an efficient method which significantly increases the % platinum (Pt) content along with the product yield. Dendrimers showed reproducible (∼27%) platinum loading by weight. Variation in core and generations does not produce significant change in the % Pt content. Percentage Pt content of dendrimeric formulation increases with increase in drug/dendrimer mole ratio. Formulation with low drug/dendrimer mole ratio showed delayed release compared to the higher drug/dendrimer mole ratio; these dendrimer formulations are stable in room temperature. In vitro release profiles of the stored dendrimer-cisplatin samples showed comparatively slow release of cisplatin, which may be due to formation of strong bond between cisplatin and dendrimer. This study will contribute to create a fine print for the formulation development of PAMAM dendrimer-cisplatin complexes.
=>発達, 開発, 産物, 進展
Overview of noun development
The noun development has 9 senses (first 7 from tagged texts)
1. (52) development -- (act of improving by expanding or enlarging or refining; "he congratulated
them on their development of a plan to meet the emergency"; "they funded research and development")
2. (46) development, evolution -- (a process in which something passes by degrees to a different
stage (especially a more advanced or mature stage); "the development of his ideas took many years";
"the evolution of Greek civilization"; "the slow development of her skill as a writer")
3. (11) growth, growing, maturation, development, ontogeny, ontogenesis -- ((biology) the process of
an individual organism growing organically; a purely biological unfolding of events involved in an
organism changing gradually from a simple to a more complex level; "he proposed an indicator of
osseous development in children")
4. (9) development -- (a recent event that has some relevance for the present situation; "recent
developments in Iraq"; "what a revolting development!")
5. (7) exploitation, development -- (the act of making some area of land or water more profitable or
productive or useful; "the development of Alaskan resources"; "the exploitation of copper deposits")
6. (6) development -- (a district that has been developed to serve some purpose; "such land is
practical for small park developments")
7. (4) development -- (a state in which things are improving; the result of developing (as in the
early part of a game of chess); "after he saw the latest development he changed his mind and became
a supporter"; "in chess your should take care of your development before moving your queen")
8. development, developing -- (processing a photosensitive material in order to make an image
visible; "the development and printing of his pictures took only two hours")
9. development -- ((music) the section of a composition or movement (especially in sonata form)
where the major musical themes are developed and elaborated)
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