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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for different out of >500 occurrences
683276 occurrences (No.7 in the rank) during 5 years in the PubMed. [cache]
15) polii belongs to the genus Holothuria, the lacking of sulfate group and the fact that it contains up to six monosaccharides make it different from this genus.
--- ABSTRACT ---
PMID:23188650 DOI:10.1177/0748233712466135
2015 Toxicology and industrial health
* Structure elucidation, protein profile and the antitumor effect of the biological active substance extracted from sea cucumber Holothuria polii.
- Holothuria polii (Delle Chiaje, 1823) (Holothuriidae) is a sea cucumber inhabiting Mediterranean Sea coast of Egypt. The bioactive compound of its tegument has antifungal, antibacterial and antiparasitic effects. The present study aims to elucidate the structure of the bioactive material of H. polii for pharmacological and chemotaxonomic purposes. Furthermore, the study demonstrates its efficacy as a cytotoxic agents against two tumor cell lines HCT116 (colon adenocarcinoma cell line) and MCF7 (breast adenocarcinoma cell line). The biological active compound of the ethanol extract has been characterized by means of infrared (IR), proton-nuclear magnetic resonance ((1)H NMR), ultraviolet-visible (UV-Vis) and mass spectra. Protein profile was carried out using sodium dodecyl sulfate polyacrylamide gel electrophoresis. Cytotoxic activity was carried out according to sulforhodamine-B assay. IR, (1)H NMR, UV-Vis and mass spectra showed that the extracted bioactive material is a nonsulfated hexaosides called bivittoside. This glycoside is composed of aglycone and a glycosidic chain (carbohydrate chain) enclosed with six sugar units, including xylose, glucose, 3-O-methylglucose and quinovose. There were no traces of dissolved proteins. The preliminary cytotoxic assay of bivittoside exhibited significant cytotoxic activity against two types of cultured tumor cell lines of HCT116 and MCF7. The half-maximal inhibitory concentration was 17.4 µg/ml and 18 µg/ml for MCF7 and HCT116, respectively. Although H. polii belongs to the genus Holothuria, the lacking of sulfate group and the fact that it contains up to six monosaccharides make it different from this genus. The present study suggests separation of H. polii from its genus to a new one. On the other hand, results support the hypothesis that H. polii bioactive compound has an antitumor effect.
[frequency of next (right) word to different]
(1)21 from (18)3 amounts (35)2 compared (52)2 origins
(2)15 types (19)3 aspects (36)2 dietary (53)2 output
(3)10 between (20)3 cell (37)2 diseases (54)2 pHs
(4)9 doses (21)3 degrees (38)2 dosing (55)2 patterns
(5)7 concentrations (22)3 effects (39)2 ethnic (56)2 perspectives
(6)6 time (23)3 for (40)2 flow (57)2 protocols
(7)5 in (24)3 health (41)2 frequencies (58)2 range
(8)5 levels (25)3 mechanisms (42)2 gene (59)2 regions
(9)4 *null* (26)3 parts (43)2 genes (60)2 scenarios
(10)4 areas (27)3 roles (44)2 genetic (61)2 sensory
(11)4 combinations (28)3 species (45)2 human (62)2 surface
(12)4 components (29)3 ways (46)2 indicators (63)2 taxa
(13)4 groups (30)2 abutments (47)2 internal-cone (64)2 than
(14)4 methods (31)2 and (48)2 laser (65)2 therapeutic
(15)4 stages (32)2 approaches (49)2 masking (66)2 tissues
(16)4 tilt (33)2 bleaching (50)2 materials (67)2 versions
(17)3 adhesive (34)2 changes (51)2 molecular (68)2 views

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--- WordNet output for different --- =>いろいろな, 違った, 異なった, 様々の, 種々の, 異なる, 変わった Overview of adj different The adj different has 5 senses (first 4 from tagged texts) 1. (88) different -- (unlike in nature or quality or form or degree; "took different approaches to the problem"; "came to a different conclusion"; "different parts of the country"; "on different sides of the issue"; "this meeting was different from the earlier one") 2. (41) different -- (distinctly separate from the first; "that's another (or different) issue altogether") 3. (2) different -- (differing from all others; not ordinary; "advertising that strives continually to be different"; "this new music is certainly different but I don't really like it") 4. (1) unlike, dissimilar, different -- (marked by dissimilarity; "for twins they are very unlike"; "people are profoundly different") 5. different -- (distinct or separate; "each interviewed different members of the community") --- WordNet end ---