167) No study has compared 2 different dosing strategies for argatroban titration nor has any published nomogram demonstrated improvement in outcomes. |
PMID:23965335 DOI:10.1177/1076029613501542 |
2015 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis |
* Evaluation of 2 nomogram-based strategies for dosing argatroban in patients with known or suspected heparin-induced thrombocytopenia. |
- No study has compared 2 different dosing strategies for argatroban titration nor has any published nomogram demonstrated improvement in outcomes. This study was conducted to evaluate the effectiveness of 2 argatroban nomograms on reaching therapeutic anticoagulation. Patients treated with argatroban were separated into 2 sliding scale groups, percentage adjustments (PAs) and predefined dose increments (PDIs). The primary outcome was the time to reach a therapeutic activated partial thromboplastin time (aPTT). The average initial dose and dose to achieve a therapeutic aPTT were similar between the groups. There was also no difference in the number of dose changes. The time to reach a therapeutic aPTT was 2 hours shorter in the PDI compared to the PA group, 8 ± 4 hours versus 10 ± 4 hours, P = .015. This study demonstrates a significant time advantage associated with a PDI nomogram compared to a PA nomogram but no difference with respect to the number of rate changes. |
(1)21 from | (18)3 amounts | (35)2 compared | (52)2 origins |
(2)15 types | (19)3 aspects | (36)2 dietary | (53)2 output |
(3)10 between | (20)3 cell | (37)2 diseases | (54)2 pHs |
(4)9 doses | (21)3 degrees | (38)2 dosing | (55)2 patterns |
(5)7 concentrations | (22)3 effects | (39)2 ethnic | (56)2 perspectives |
(6)6 time | (23)3 for | (40)2 flow | (57)2 protocols |
(7)5 in | (24)3 health | (41)2 frequencies | (58)2 range |
(8)5 levels | (25)3 mechanisms | (42)2 gene | (59)2 regions |
(9)4 *null* | (26)3 parts | (43)2 genes | (60)2 scenarios |
(10)4 areas | (27)3 roles | (44)2 genetic | (61)2 sensory |
(11)4 combinations | (28)3 species | (45)2 human | (62)2 surface |
(12)4 components | (29)3 ways | (46)2 indicators | (63)2 taxa |
(13)4 groups | (30)2 abutments | (47)2 internal-cone | (64)2 than |
(14)4 methods | (31)2 and | (48)2 laser | (65)2 therapeutic |
(15)4 stages | (32)2 approaches | (49)2 masking | (66)2 tissues |
(16)4 tilt | (33)2 bleaching | (50)2 materials | (67)2 versions |
(17)3 adhesive | (34)2 changes | (51)2 molecular | (68)2 views |
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