ELIZA

return kwic search for disease out of >500 occurrences
422715 occurrences (No.39 in the rank) during 5 years in the PubMed. [no cache] 500 found

254) Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described in various types of cancers and might be associated with cancer risk and disease outcome.

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PMID:24021012 DOI:10.3109/19401736.2013.825772

2015 Mitochondrial DNA

* Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA is associated with renal cell carcinoma outcome.

- Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described in various types of cancers and might be associated with cancer risk and disease outcome. We identified 14 SNPs with a frequency higher than 5% and 5 SNPs associated with the risk of renal cell carcinoma (RCC) in a case-control study previously. In the present study, we assessed the relationship of these SNPs and the outcome of RCC patients, a SNP of 262C/T was identified by the log-rank test for statistically significant prediction of RCC survival. In an overall multivariate analysis, allele 262 was identified as an independent predictor of RCC outcome. The length of survival of patients with 262T was significantly shorter than that of patients with allele 262C (relative risk, 2.136, 95%CI, 1.863-2.449; p = 0.000). The analysis of genetic polymorphisms in the mitochondrial D-loop can help identify patients subgroup at high risk of a poor disease outcome.

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(1)100 null	(17)4 (PD)	(33)3 to	(49)2 condition,
(2)39 and	(18)4 activity	(34)2 (CHD)	(50)2 development
(3)16 is	(19)4 outcome	(35)2 (COPD)	(51)2 interval
(4)13 in	(20)4 severity,	(36)2 (CVD),	(52)2 many
(5)12 of	(21)4 the	(37)2 (GERD)	(53)2 multi-sectoral
(6)9 (FMD)	(22)4 who	(38)2 (LSD)	(54)2 on
(7)8 risk	(23)3 (CAD)	(39)2 (SC)	(55)2 onset
(8)7 severity	(24)3 compared	(40)2 Control	(56)2 onset,
(9)6 progression	(25)3 control	(41)2 activity,	(57)2 outbreaks
(10)6 that	(26)3 course	(42)2 are	(58)2 patterns
(11)6 was	(27)3 free	(43)2 as	(59)2 phobia
(12)5 (CVD)	(28)3 has	(44)2 associated	(60)2 prevention
(13)5 or	(29)3 management	(45)2 burden	(61)2 processes
(14)5 state	(30)3 may	(46)2 by	(62)2 progression,
(15)4 (AD)	(31)3 patients	(47)2 can	(63)2 surveillance
(16)4 (HD)	(32)3 states	(48)2 characterized	(64)2 usually

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--- WordNet output for disease --- =>病気, 病弊, 精神の退廃 Overview of noun disease The noun disease has 1 sense (first 1 from tagged texts) 1. (26) disease -- (an impairment of health or a condition of abnormal functioning) --- WordNet end ---