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422715 occurrences (No.39 in the rank) during 5 years in the PubMed. [cache]
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422715 occurrences (No.39 in the rank) during 5 years in the PubMed. [cache]
| 364) Insulin-dependent diabetes mellitus (IDDM) is a metabolic disease usually resulting from autoimmune-mediated β-cell destruction requiring lifetime exogenous insulin replacement. |
| PMID:24317657 DOI:10.1007/s10238-013-0266-1 |
| 2015 Clinical and experimental medicine |
| * Novel therapy for insulin-dependent diabetes mellitus: infusion of in vitro-generated insulin-secreting cells. |
| - Insulin-dependent diabetes mellitus (IDDM) is a metabolic disease usually resulting from autoimmune-mediated β-cell destruction requiring lifetime exogenous insulin replacement. Mesenchymal stem cells (MSC) hold promising therapy. We present our experience of treating IDDM with co-infusion of in vitro autologous adipose tissue-derived MSC-differentiated insulin-secreting cells (ISC) with hematopoietic stem cells (HSC). This was an Institutional Review Board approved prospective non-randomized open-labeled clinical trial after informed consent from ten patients. ISC were differentiated from autologous adipose tissue-derived MSC and were infused with bone marrow-derived HSC in portal, thymic circulation by mini-laparotomy and in subcutaneous circulation. Patients were monitored for blood sugar levels, serum C-peptide levels, glycosylated hemoglobin (Hb1Ac) and glutamic acid decarboxylase (GAD) antibodies. Insulin administration was made on sliding scale with an objective of maintaining FBS < 150 mg/dL and PPBS around 200 mg/dL. Mean 3.34 mL cell inoculums with 5.25 × 10(4) cells/μL were infused. No untoward effects were observed. Over a mean follow-up of 31.71 months, mean serum C-peptide of 0.22 ng/mL before infusion had sustained rise of 0.92 ng/mL with decreased exogenous insulin requirement from 63.9 international units (IU)/day to 38.6 IU/day. Improvement in mean Hb1Ac was observed from 10.99 to 6.72%. Mean GAD antibodies were positive in all patients with mean of 331.10 IU/mL, which decreased to mean of 123 IU/mL. Co-infusion of autologous ISC with HSC represents a viable novel therapeutic option for IDDM. |
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| (3)16 is |
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(21)4 the |
(37)2 (GERD) |
(53)2 multi-sectoral |
| (6)9 (FMD) |
(22)4 who |
(38)2 (LSD) |
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(23)3 (CAD) |
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(60)2 prevention |
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| (15)4 (AD) |
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(63)2 surveillance |
| (16)4 (HD) |
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--- WordNet output for disease ---