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324863 occurrences (No.63 in the rank) during 5 years in the PubMed. [cache]

10) Due to its intrinsic biocompatibility, HA allowed the exploitation of different injection routes and did not induce inflammation at the inoculation site.

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PMID:33762685 DOI:10.1038/s41423-021-00667-y

2021 Cellular & molecular immunology

* Hyaluronan is a natural and effective immunological adjuvant for protein-based vaccines.

- One of the main goals of vaccine research is the development of adjuvants that can enhance immune responses and are both safe and biocompatible. We explored the application of the natural polymer hyaluronan (HA) as a promising immunological adjuvant for protein-based vaccines. Chemical conjugation of HA to antigens strongly increased their immunogenicity, reduced booster requirements, and allowed antigen dose sparing. HA-based bioconjugates stimulated robust and long-lasting humoral responses without the addition of other immunostimulatory compounds and proved highly efficient when compared to other adjuvants. Due to its intrinsic biocompatibility, HA allowed the exploitation of different injection routes and did not induce inflammation at the inoculation site. This polymer promoted rapid translocation of the antigen to draining lymph nodes, thus facilitating encounters with antigen-presenting cells. Overall, HA can be regarded as an effective and biocompatible adjuvant to be exploited for the design of a wide variety of vaccines.

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--- WordNet output for due --- =>1.予定の, 支払期日がきて, 当然支払われるべき, 2.支払[提出]期日, 満期日, 会費 Overview of noun due The noun due has 2 senses (first 1 from tagged texts) 1. (4) due -- (that which is deserved or owed; "give the devil his due") 2. due -- (a payment that is due (e.g., as the price of membership); "the society dropped him for non-payment of dues") Overview of adj due The adj due has 4 senses (first 2 from tagged texts) 1. (6) due -- (owed and payable immediately or on demand; "payment is due") 2. (1) due -- (scheduled to arrive; "the train is due in 15 minutes") 3. due -- (suitable to or expected in the circumstances; "all due respect"; "due cause to honor them"; "a long due promotion"; "in due course"; "due esteem"; "exercising due care") 4. ascribable, due, imputable, referable -- (capable of being assigned or credited to; "punctuation errors ascribable to careless proofreading"; "the cancellation of the concert was due to the rain"; "the oversight was not imputable to him") Overview of adv due The adv due has 1 sense (no senses from tagged texts) 1. due -- (directly or exactly; straight; "went due North") --- WordNet end ---