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return kwic search for effect out of >500 occurrences
566982 occurrences (No.17 in the rank) during 5 years in the PubMed. [cache]

408) Implant-blood contact experiments confirmed the strong coagulatory effect for Ca surfaces.

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PMID:34453217 DOI:10.1007/s00775-021-01886-4

2021 Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

* Protein adsorption/desorption dynamics on Ca-enriched titanium surfaces: biological implications.

- Calcium ions are used in the development of biomaterials for the promotion of coagulation, bone regeneration, and implant osseointegration. Upon implantation, the time-dependent release of calcium ions from titanium implant surfaces modifies the physicochemical characteristics at the implant-tissue interface and thus, the biological responses. The aim of this study is to examine how the dynamics of protein adsorption on these surfaces change over time. Titanium discs with and without Ca were incubated with human serum for 2 min, 180 min, and 960 min. The layer of proteins attached to the surface was characterised using nLC-MS/MS. The adsorption kinetics was different between materials, revealing an increased adsorption of proteins associated with coagulation and immune responses prior to Ca release. Implant-blood contact experiments confirmed the strong coagulatory effect for Ca surfaces. We employed primary human alveolar osteoblasts and THP-1 monocytes to study the osteogenic and inflammatory responses. In agreement with the proteomic results, Ca-enriched surfaces showed a significant initial inflammation that disappeared once the calcium was released. The distinct protein adsorption/desorption dynamics found in this work demonstrated to be useful to explain the differential biological responses between the titanium and Ca-ion modified implant surfaces.

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(1)219 of	(8)11 sizes	(15)3 to	(22)2 measure
(2)66 on	(9)9 is	(16)3 via	(23)2 relationship
(3)30 null	(10)4 against	(17)3 with	(24)2 than
(4)20 and	(11)4 for	(18)2 P	(25)2 trials
(5)19 in	(12)4 such	(19)2 at
(6)16 was	(13)4 that	(20)2 estimates,
(7)13 size	(14)3 may	(21)2 induced

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--- WordNet output for effect --- =>趣旨, 結果, 影響, 効力, 活動, 印象, 効果, 成し遂げる Overview of noun effect The noun effect has 6 senses (first 5 from tagged texts) 1. (101) consequence, effect, outcome, result, event, issue, upshot -- (a phenomenon that follows and is caused by some previous phenomenon; "the magnetic effect was greater when the rod was lengthwise"; "his decision had depressing consequences for business"; "he acted very wise after the event") 2. (11) impression, effect -- (an outward appearance; "he made a good impression"; "I wanted to create an impression of success"; "she retained that bold effect in her reproductions of the original painting") 3. (9) effect -- (an impression (especially one that is artificial or contrived); "he just did it for effect") 4. (2) effect, essence, burden, core, gist -- (the central meaning or theme of a speech or literary work) 5. (1) effect, force -- ((of a law) having legal validity; "the law is still in effect") 6. effect -- (a symptom caused by an illness or a drug; "the effects of sleep loss"; "the effect of the anesthetic") Overview of verb effect The verb effect has 2 senses (first 2 from tagged texts) 1. (17) effect, effectuate, set up -- (produce; "The scientists set up a shock wave") 2. (3) effect -- (act so as to bring into existence; "effect a change") --- WordNet end ---