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286252 occurrences (No.88 in the rank) during 5 years in the PubMed. [no cache] 500 found
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286252 occurrences (No.88 in the rank) during 5 years in the PubMed. [no cache] 500 found
| 124) Using the HpPKC-I, we have demonstrated further that PKC not only determines cell-specific nucleation of β-catenin, but also regulates a variety of cell specification events in the early sea urchin embryos by modulating the cell adhesion structures, actin dynamics, intracellular Ca2+ signalling, and the expression of key transcription factors. |
| PMID:24717667 DOI:10.1017/S0967199414000033 |
| 2015 Zygote (Cambridge, England) |
| * Ca²⁺ influx-linked protein kinase C activity regulates the β-catenin localization, micromere induction signalling and the oral-aboral axis formation in early sea urchin embryos. |
| - Sea urchin embryos initiate cell specifications at the 16-cell stage by forming the mesomeres, macromeres and micromeres according to the relative position of the cells in the animal-vegetal axis. The most vegetal cells, micromeres, autonomously differentiate into skeletons and induce the neighbouring macromere cells to become mesoendoderm in the β-catenin-dependent Wnt8 signalling pathway. Although the underlying molecular mechanism for this progression is largely unknown, we have previously reported that the initial events might be triggered by the Ca2+ influxes through the egg-originated L-type Ca2+ channels distributed asymmetrically along the animal-vegetal axis and through the stretch-dependent Ca2+channels expressed specifically in the micromere at the 4th cleavage. In this communication, we have examined whether one of the earliest Ca2+ targets, protein kinase C (PKC), plays a role in cell specification upstream of β-catenin. To this end, we surveyed the expression pattern of β-catenin in early embryos in the presence or absence of the specific peptide inhibitor of Hemicentrotus pulcherrimus PKC (HpPKC-I). Unlike previous knowledge, we have found that the initial nuclear entrance of β-catenin does not take place in the micromeres, but in the macromeres at the 16-cell stage. Using the HpPKC-I, we have demonstrated further that PKC not only determines cell-specific nucleation of β-catenin, but also regulates a variety of cell specification events in the early sea urchin embryos by modulating the cell adhesion structures, actin dynamics, intracellular Ca2+ signalling, and the expression of key transcription factors. |
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(44)2 cell |
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(16)3 multiple |
(30)2 P2X3 |
(45)2 constitutively |
| (3)9 genes |
(17)3 ncRAN |
(32)2 Sema |
(46)2 hyaluronan |
| (4)8 several |
(18)3 nicotine-induced |
(33)2 Siglec-9 |
(47)2 imprinted |
| (5)6 miR-218 |
(19)3 nuclear |
(34)2 TAF4 |
(48)2 intercellular |
| (6)5 these |
(20)3 specific |
(35)2 Wnt |
(49)2 membrane |
| (7)4 VEGF |
(21)3 this |
(36)2 acetyl-CoA |
(50)2 miR-128 |
| (8)4 first |
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(37)2 adhesion |
(51)2 napsin |
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(23)2 Caspase |
(38)2 adiponectin |
(52)2 phosphorylated |
| (10)3 CYP1A1 |
(24)2 FBP1 |
(39)2 angiogenic |
(53)2 piRNA-823 |
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(25)2 GABAA |
(40)2 anti-apoptotic |
(54)2 pro-inflammatory |
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(26)2 GLP-1R |
(41)2 b-FGF, |
(55)2 some |
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(27)2 Ki-67, |
(42)2 c-Myc |
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| (14)3 integrin |
(28)2 LOX-1 |
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