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286252 occurrences (No.88 in the rank) during 5 years in the PubMed. [no cache] 500 found

167) Here, we show that expression of TAF4 alternative splice variants is different in various regions of the human brain, substantiating the role of alternative splicing of TAF4 in the regulation of neural development and brain function.

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PMID:24696168 DOI:10.1007/s12031-014-0295-6

2015 Journal of molecular neuroscience : MN

* TAF4 controls differentiation of human neural progenitor cells through hTAF4-TAFH activity.

- Expression of general transcription factor and co-activator TAF4 varies during development and in the processes of cell differentiation with suggested connection to neurodegenerative diseases. Here, we show that expression of TAF4 alternative splice variants is different in various regions of the human brain, substantiating the role of alternative splicing of TAF4 in the regulation of neural development and brain function. Most of the described splicing events affect the TAFH homology domain of TAF4 (hTAF4-TAFH). Besides, differentiated towards neural lineages, normal human neural progenitors (NHNPs) lose canonical full-length TAF4 isoform. To study the effects of hTAF4-TAFH splicing on neuronal differentiation, we used RNAi approach to target hTAF4-TAFH-encoding domain in NHNPs. Results show that inactivation of hTAF4-TAFH domain accelerates differentiation of human neural progenitor cells. Conversely, enhanced expression of TAF4 suppresses differentiation and keeps neural progenitor cells in a stem cell-like state. Finally, we provide data on the involvement of TP53 and noncanonical WNT signaling pathways in mediating effects of TAF4 on neuronal differentiation. Overall, our data suggest that specific isoforms of TAF4 may selectively and efficiently control neurogenesis.

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(1)55 the	(15)3 key	(29)2 P-selectin,	(44)2 cell
(2)11 a	(16)3 multiple	(30)2 P2X3	(45)2 constitutively
(3)9 genes	(17)3 ncRAN	(32)2 Sema	(46)2 hyaluronan
(4)8 several	(18)3 nicotine-induced	(33)2 Siglec-9	(47)2 imprinted
(5)6 miR-218	(19)3 nuclear	(34)2 TAF4	(48)2 intercellular
(6)5 these	(20)3 specific	(35)2 Wnt	(49)2 membrane
(7)4 VEGF	(21)3 this	(36)2 acetyl-CoA	(50)2 miR-128
(8)4 first	(22)2 AdipoR1	(37)2 adhesion	(51)2 napsin
(9)4 matrix	(23)2 Caspase	(38)2 adiponectin	(52)2 phosphorylated
(10)3 CYP1A1	(24)2 FBP1	(39)2 angiogenic	(53)2 piRNA-823
(11)3 DNMT1	(25)2 GABAA	(40)2 anti-apoptotic	(54)2 pro-inflammatory
(12)3 all	(26)2 GLP-1R	(41)2 b-FGF,	(55)2 some
(13)3 cardiac	(27)2 Ki-67,	(42)2 c-Myc	(56)2 three
(14)3 integrin	(28)2 LOX-1	(43)2 cartilage

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--- WordNet output for expression --- =>表現すること, 式, 表現, 表示, 言い回し, 表現法, 表情 Overview of noun expression The noun expression has 9 senses (first 6 from tagged texts) 1. (23) expression, look, aspect, facial expression, face -- (the feelings expressed on a person's face; "a sad expression"; "a look of triumph"; "an angry face") 2. (18) expression, manifestation, reflection, reflexion -- (expression without words; "tears are an expression of grief"; "the pulse is a reflection of the heart's condition") 3. (15) expression, verbal expression, verbalism -- (the communication (in speech or writing) of your beliefs or opinions; "expressions of good will"; "he helped me find verbal expression for my ideas"; "the idea was immediate but the verbalism took hours") 4. (5) saying, expression, locution -- (a word or phrase that particular people use in particular situations; "pardon the expression") 5. (4) formulation, expression -- (the style of expressing yourself; "he suggested a better formulation"; "his manner of expression showed how much he cared") 6. (4) formula, expression -- (a group of symbols that make a mathematical statement) 7. expression -- ((genetics) the process of expressing a gene) 8. construction, grammatical construction, expression -- (a group of words that form a constituent of a sentence and are considered as a single unit; "I concluded from his awkward constructions that he was a foreigner") 9. expression -- (the act of forcing something out by squeezing or pressing; "the expression of milk from her breast") --- WordNet end ---