ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for expression of out of >500 occurrences
286252 occurrences (No.88 in the rank) during 5 years in the PubMed. [no cache] 500 found
4) Expression of the pro-forms of the inflammasome targets IL-1β and IL-18 were also up-regulated.
--- ABSTRACT ---
PMID:24652041 DOI:10.1177/1753425914526074
2015 Innate immunity
* The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media.
- This study was designed to understand the contribution of the inflammasome and IL-1β activation in otitis media (OM). We examined the middle ear (ME) response to non-typeable Haemophilus influenzae (NTHi) in wild type (WT) mice using gene microarrays and a murine model of acute OM. Expression of members of the NOD domain-like receptor family of inflammasome genes was significantly up-regulated early in NTHi infection of the ME, potentially activating specific downstream regulatory cascades that contribute to the proliferative inflammatory response observed during OM. Expression of the pro-forms of the inflammasome targets IL-1β and IL-18 were also up-regulated. To evaluate the role of inflammasome-mediated cytokine maturation, NTHi-induced OM was examined in Asc(-/-)-deficient mice and compared with that seen in WT mice. Mice lacking the Asc gene showed near absence of IL-1β maturation in the ME and a reduction in leukocyte recruitment and infiltration to the cavity, and their macrophages exhibited reduced phagocytosis of NTHi. These inflammatory defects were linked to an increase in the degree and duration of mucosal epithelial hyperplasia in the ME of Asc(-/-) mice, as well as a delay in bacterial clearance from their MEs. These data demonstrate an important role for the inflammasome and cytokine processing in the course and resolution of OM.
--- ABSTRACT END ---
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(1)55 the (15)3 key (29)2 P-selectin, (44)2 cell
(2)11 a (16)3 multiple (30)2 P2X3 (45)2 constitutively
(3)9 genes (17)3 ncRAN (32)2 Sema (46)2 hyaluronan
(4)8 several (18)3 nicotine-induced (33)2 Siglec-9 (47)2 imprinted
(5)6 miR-218 (19)3 nuclear (34)2 TAF4 (48)2 intercellular
(6)5 these (20)3 specific (35)2 Wnt (49)2 membrane
(7)4 VEGF (21)3 this (36)2 acetyl-CoA (50)2 miR-128
(8)4 first (22)2 AdipoR1 (37)2 adhesion (51)2 napsin
(9)4 matrix (23)2 Caspase (38)2 adiponectin (52)2 phosphorylated
(10)3 CYP1A1 (24)2 FBP1 (39)2 angiogenic (53)2 piRNA-823
(11)3 DNMT1 (25)2 GABAA (40)2 anti-apoptotic (54)2 pro-inflammatory
(12)3 all (26)2 GLP-1R (41)2 b-FGF, (55)2 some
(13)3 cardiac (27)2 Ki-67, (42)2 c-Myc (56)2 three
(14)3 integrin (28)2 LOX-1 (43)2 cartilage

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--- WordNet output for expression --- =>表現すること, 式, 表現, 表示, 言い回し, 表現法, 表情 Overview of noun expression The noun expression has 9 senses (first 6 from tagged texts) 1. (23) expression, look, aspect, facial expression, face -- (the feelings expressed on a person's face; "a sad expression"; "a look of triumph"; "an angry face") 2. (18) expression, manifestation, reflection, reflexion -- (expression without words; "tears are an expression of grief"; "the pulse is a reflection of the heart's condition") 3. (15) expression, verbal expression, verbalism -- (the communication (in speech or writing) of your beliefs or opinions; "expressions of good will"; "he helped me find verbal expression for my ideas"; "the idea was immediate but the verbalism took hours") 4. (5) saying, expression, locution -- (a word or phrase that particular people use in particular situations; "pardon the expression") 5. (4) formulation, expression -- (the style of expressing yourself; "he suggested a better formulation"; "his manner of expression showed how much he cared") 6. (4) formula, expression -- (a group of symbols that make a mathematical statement) 7. expression -- ((genetics) the process of expressing a gene) 8. construction, grammatical construction, expression -- (a group of words that form a constituent of a sentence and are considered as a single unit; "I concluded from his awkward constructions that he was a foreigner") 9. expression -- (the act of forcing something out by squeezing or pressing; "the expression of milk from her breast") --- WordNet end ---