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295043 occurrences (No.82 in the rank) during 5 years in the PubMed. [no cache] 500 found

353) The three markers are highly associated prognostic factors to diseases severity.

--- ABSTRACT ---

PMID:24070129 DOI:10.3109/13816810.2013.838276

2015 Ophthalmic genetics

* Association of SOD2 Mutation (c.47T > C) with Various Primary Angle Closure Glaucoma Clinical Indices.

- We investigated whether the c.47T>C polymorphism (SNP rs4880) in the manganese superoxide dismutase (SOD2) gene is a risk factor for primary angle closure glaucoma (PACG) in the Saudi population. Among cases (n=139), the prevalence of various genotypes were 25.9%, 46.8% and 27.3% for T/T, C/T and C/C genotypes respectively. This trend was similar in the controls (n=403); 22.6%, 50.1% and 27.3% for T/T, C/T and C/C respectively. The differences in genotype distribution were not statistically significant (p=0.391 and 0.682 respectively). The minor allele frequency was 50.7% in cases and 52.4% in controls; this difference was not statistically significant (p=0.676). Investigating the potential association between this SOD2 polymorphism and different clinical indices, there was a statistically significant difference among different genotype groups in terms of three important clinical indices for PACG; Mean age at onset, duration of onset to and the mean LogMAR visual acuity (p=0.041, 0.018 and 0.033 respectively). The three markers are highly associated prognostic factors to diseases severity. If our results are proven in larger cohort and in various populations, then this SNP may have potentiality to be used as an indicator for PACG severity.

--- ABSTRACT END ---

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(1)62 for	(12)10 related	(23)3 using	(34)2 during
(2)44 null	(13)8 on	(24)3 which	(35)2 from
(3)36 that	(14)7 have	(25)3 with	(36)2 including
(4)34 associated	(15)7 such	(26)2 (age,	(37)2 independently
(5)31 and	(16)6 may	(27)2 along	(38)2 involved
(6)29 in	(17)4 influence	(28)2 as	(39)2 jointly
(7)20 were	(18)4 significantly	(29)2 c-Jun	(40)2 other
(8)14 influencing	(19)4 to	(30)2 can	(41)2 produced
(9)13 are	(20)3 across	(31)2 contribute	(42)2 was
(10)13 of	(21)3 among	(32)2 contributing
(11)10 affecting	(22)3 like	(33)2 diagnostic

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--- WordNet output for factors --- Overview of noun factor The noun factor has 7 senses (first 4 from tagged texts) 1. (31) factor -- (anything that contributes causally to a result; "a number of factors determined the outcome") 2. (8) component, constituent, element, factor, ingredient -- (an abstract part of something; "jealousy was a component of his character"; "two constituents of a musical composition are melody and harmony"; "the grammatical elements of a sentence"; "a key factor in her success"; "humor: an effective ingredient of a speech") 3. (4) divisor, factor -- (one of two or more integers that can be exactly divided into another integer; "what are the 4 factors of 6?") 4. (1) agent, factor, broker -- (a businessman who buys or sells for another in exchange for a commission) 5. factor -- (any of the numbers (or symbols) that form a product when multiplied together) 6. factor -- (an independent variable in statistics) 7. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") Overview of verb factor The verb factor has 3 senses (first 1 from tagged texts) 1. (2) factor, factor in, factor out -- (resolve into factors; "a quantum computer can factor the number 15") 2. factor -- (be a contributing factor; "make things factor into a company's profitability") 3. factor, factor in, factor out -- (consider as relevant when making a decision; "You must factor in the recent developments") --- WordNet end ---