ELIZA

return kwic search for factors out of >500 occurrences
295043 occurrences (No.82 in the rank) during 5 years in the PubMed. [cache]

424) Under high-temperature stress, opportunistic fungal pathogens deploy an adaptive mechanism known as heat shock (HS) response controlled by heat shock transcription factors (HSFs).

--- ABSTRACT ---

PMID:33897671 DOI:10.3389/fmicb.2021.656548

2021 Frontiers in microbiology

* The Heat Shock Transcription Factor HsfA Is Essential for Thermotolerance and Regulates Cell Wall Integrity in Aspergillus fumigatus.

- The deleterious effects of human-induced climate change have long been predicted. However, the imminent emergence and spread of new diseases, including fungal infections through the rise of thermotolerant strains, is still neglected, despite being a potential consequence of global warming. Thermotolerance is a remarkable virulence attribute of the mold Aspergillus fumigatus. Under high-temperature stress, opportunistic fungal pathogens deploy an adaptive mechanism known as heat shock (HS) response controlled by heat shock transcription factors (HSFs). In eukaryotes, HSFs regulate the expression of several heat shock proteins (HSPs), such as the chaperone Hsp90, which is part of the cellular program for heat adaptation and a direct target of HSFs. We recently observed that the perturbation in cell wall integrity (CWI) causes concomitant susceptibility to elevated temperatures in A. fumigatus, although the mechanisms underpinning the HS response and CWI cross talking are not elucidated. Here, we aim at further deciphering the interplay between HS and CWI. Our results show that cell wall ultrastructure is severely modified when A. fumigatus is exposed to HS. We identify the transcription factor HsfA as essential for A. fumigatus viability, thermotolerance, and CWI. Indeed, HS and cell wall stress trigger the coordinated expression of both hsfA and hsp90. Furthermore, the CWI signaling pathway components PkcA and MpkA were shown to be important for HsfA and Hsp90 expression in the A. fumigatus biofilms. Lastly, RNA-sequencing confirmed that hsfA regulates the expression of genes related to the HS response, cell wall biosynthesis and remodeling, and lipid homeostasis. Our studies collectively demonstrate the connection between the HS and the CWI pathway, with HsfA playing a crucial role in this cross-pathway regulation, reinforcing the importance of the cell wall in A. fumigatus thermophily.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to factors]

(1)60 and	(12)8 related	(23)3 influence	(34)2 from
(2)55 null	(13)8 to	(24)3 is	(35)2 have
(3)41 that	(14)7 of	(25)3 relating	(36)2 impact
(4)31 for	(15)6 (e.g.,	(26)3 which	(37)2 involved
(5)29 associated	(16)6 contributing	(27)3 with	(38)2 shaping
(6)24 influencing	(17)5 on	(28)2 (including	(39)2 should
(7)20 were	(18)4 can	(29)2 (pre-COVID-19);	(40)2 using
(8)17 such	(19)4 like	(30)2 affecting	(41)2 varied
(9)15 in	(20)4 the	(31)2 and/or	(42)2 was
(10)11 are	(21)3 as	(32)2 at
(11)9 including	(22)3 included	(33)2 by

add keyword

--- WordNet output for factors --- Overview of noun factor The noun factor has 7 senses (first 4 from tagged texts) 1. (31) factor -- (anything that contributes causally to a result; "a number of factors determined the outcome") 2. (8) component, constituent, element, factor, ingredient -- (an abstract part of something; "jealousy was a component of his character"; "two constituents of a musical composition are melody and harmony"; "the grammatical elements of a sentence"; "a key factor in her success"; "humor: an effective ingredient of a speech") 3. (4) divisor, factor -- (one of two or more integers that can be exactly divided into another integer; "what are the 4 factors of 6?") 4. (1) agent, factor, broker -- (a businessman who buys or sells for another in exchange for a commission) 5. factor -- (any of the numbers (or symbols) that form a product when multiplied together) 6. factor -- (an independent variable in statistics) 7. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") Overview of verb factor The verb factor has 3 senses (first 1 from tagged texts) 1. (2) factor, factor in, factor out -- (resolve into factors; "a quantum computer can factor the number 15") 2. factor -- (be a contributing factor; "make things factor into a company's profitability") 3. factor, factor in, factor out -- (consider as relevant when making a decision; "You must factor in the recent developments") --- WordNet end ---