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295043 occurrences (No.82 in the rank) during 5 years in the PubMed. [no cache] 500 found

79) Layered chondrocyte sheets produced the most humoral factors.

--- ABSTRACT ---

PMID:23165985 DOI:10.1002/term.1610

2015 Journal of tissue engineering and regenerative medicine

* Studies of the humoral factors produced by layered chondrocyte sheets.

- The authors aimed to repair and regenerate articular cartilage with layered chondrocyte sheets, produced using temperature-responsive culture dishes. The purpose of this study was to investigate the humoral factors produced by layered chondrocyte sheets. Articular chondrocytes and synovial cells were harvested during total knee arthroplasty. After co-culture, the samples were divided into three groups: a monolayer, 7 day culture sheet group (group M); a triple-layered, 7 day culture sheet group (group L); and a monolayer culture group with a cell count identical to that of group L (group C). The secretion of collagen type 1 (COL1), collagen type 2 (COL2), matrix metalloproteinase-13 (MMP13), transforming growth factor-β (TGFβ), melanoma inhibitory activity (MIA) and prostaglandin E2 (PGE2) were measured by enzyme-linked immunosorbent assay (ELISA). Layered chondrocyte sheets produced the most humoral factors. PGE2 expression declined over time in group C but was significantly higher in groups M and L. TGFβ expression was low in group C but was significantly higher in groups M and L (p<0.05). Our results suggest that the humoral factors produced by layered chondrocyte sheets may contribute to cartilaginous tissue repair and regeneration.

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(1)62 for	(12)10 related	(23)3 using	(34)2 during
(2)44 null	(13)8 on	(24)3 which	(35)2 from
(3)36 that	(14)7 have	(25)3 with	(36)2 including
(4)34 associated	(15)7 such	(26)2 (age,	(37)2 independently
(5)31 and	(16)6 may	(27)2 along	(38)2 involved
(6)29 in	(17)4 influence	(28)2 as	(39)2 jointly
(7)20 were	(18)4 significantly	(29)2 c-Jun	(40)2 other
(8)14 influencing	(19)4 to	(30)2 can	(41)2 produced
(9)13 are	(20)3 across	(31)2 contribute	(42)2 was
(10)13 of	(21)3 among	(32)2 contributing
(11)10 affecting	(22)3 like	(33)2 diagnostic

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--- WordNet output for factors --- Overview of noun factor The noun factor has 7 senses (first 4 from tagged texts) 1. (31) factor -- (anything that contributes causally to a result; "a number of factors determined the outcome") 2. (8) component, constituent, element, factor, ingredient -- (an abstract part of something; "jealousy was a component of his character"; "two constituents of a musical composition are melody and harmony"; "the grammatical elements of a sentence"; "a key factor in her success"; "humor: an effective ingredient of a speech") 3. (4) divisor, factor -- (one of two or more integers that can be exactly divided into another integer; "what are the 4 factors of 6?") 4. (1) agent, factor, broker -- (a businessman who buys or sells for another in exchange for a commission) 5. factor -- (any of the numbers (or symbols) that form a product when multiplied together) 6. factor -- (an independent variable in statistics) 7. gene, cistron, factor -- ((genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors") Overview of verb factor The verb factor has 3 senses (first 1 from tagged texts) 1. (2) factor, factor in, factor out -- (resolve into factors; "a quantum computer can factor the number 15") 2. factor -- (be a contributing factor; "make things factor into a company's profitability") 3. factor, factor in, factor out -- (consider as relevant when making a decision; "You must factor in the recent developments") --- WordNet end ---