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299123 occurrences (No.77 in the rank) during 5 years in the PubMed. [cache]

21) These findings suggest that Ket/Xyl administration can have substantial effect on acute pancreatitis outcomes through nonmuscarinic neural pathways.

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PMID:33881355 DOI:10.1152/ajpgi.00023.2021

2021 American journal of physiology. Gastrointestinal and liver physiology

* Ketamine and xylazine effects in murine model of acute pancreatitis.

- Ketamine and xylazine (Ket/Xyl) are anesthetic agents that target neural pathways and are commonly used in combination in mouse studies. Since neural pathways can modulate acute pancreatitis severity, we asked if Ket/Xyl affect disease severity. C57BL/6 mice were treated with six hourly injections of cerulein to induce mild acute pancreatitis. Mice were also treated with and without ketamine, xylazine, and Ket/Xyl before pancreatitis induction in vivo and in vitro. Ket/Xyl pretreatment in vivo increased selected parameters of pancreatitis severity such as trypsin activity and edema; these effects were predominantly mediated by xylazine. Ket/Xyl also changed markers of autophagy. These in vivo effects of Ket/Xyl were not attenuated by atropine. The drugs had no little to no effect on pancreatitis responses in isolated pancreatic cells or lobules. These findings suggest that Ket/Xyl administration can have substantial effect on acute pancreatitis outcomes through nonmuscarinic neural pathways. Given widespread use of this anesthetic combination in experimental animal models, future studies of inflammation and injury using Ket/Xyl should be interpreted with caution.NEW & NOTEWORTHY Ketamine and xylazine anesthetic agent administration before acute pancreatitis induction in mice lead to changes in pancreatitis responses independent of acute pancreatitis induction. Future studies should consider the potential effects of anesthesia administration when studying disease processes associated with inflammation and injury.

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(1)49 suggest	(13)9 support	(25)4 that	(37)2 encourage
(2)40 from	(14)9 will	(26)4 to	(38)2 illuminate
(3)36 of	(15)6 include	(27)4 we	(39)2 it
(4)33 null	(16)6 reveal	(28)3 also	(40)2 may
(5)25 were	(17)6 revealed	(29)3 further	(41)2 open
(6)24 and	(18)5 for	(30)3 presented	(42)2 suggested
(7)21 indicate	(19)5 regarding	(31)3 related	(43)2 the
(8)18 provide	(20)5 showed	(32)3 reported	(44)2 through
(9)17 are	(21)4 can	(33)3 with	(45)2 uncover
(10)15 in	(22)4 demonstrate	(34)2 by	(46)2 underline
(11)11 highlight	(23)4 have	(35)2 confirm
(12)9 on	(24)4 show	(36)2 emphasize

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--- WordNet output for findings --- =>研究(調査)結果 Overview of noun findings The noun findings has 1 sense (no senses from tagged texts) 1. findings -- (a collection of tools and other articles used by an artisan to make jewelry or clothing or shoes) Overview of noun finding The noun finding has 3 senses (first 3 from tagged texts) 1. (16) determination, finding -- (the act of determining the properties of something, usually by research or calculation; "the determination of molecular structures") 2. (3) finding -- (the decision of a court on issues of fact or law) 3. (1) finding -- (something that is found; "the findings in the gastrointestinal tract indicate that he died several hours after dinner"; "an area rich in archaeological findings") --- WordNet end ---