* Treatment with garlic restores membrane thiol content and ameliorates lead induced early death of erythrocytes in mice.
- Sequelae of chronic lead (Pb(2+) ) toxicity includes anemia that is partially due to early death of erythrocytes characterized by excess accumulation of ROS and downregulation of antioxidant system causing oxidative stress and externalization of phosphatidylserine. In this study, pathophysiological based therapeutic application of garlic was evaluated against erythrocyte death. Results suggest that garlic administration prevents oxidative stress, restored the antioxidant balance in erythrocytes of Pb(2+) exposed mice. Moreover, in vitro studies revealed that activity of both scramblase and aminophospholipid translocase could be changed by modifying the critical sulfhydryl groups in presence of dithiothreitol during Pb(2+) exposure. Data also indicated that garlic treatment in Pb(2+) exposed mice exhibited sharp decline in PS exposure and increase in erythrocyte membrane thiol group followed by increase in aminophospholipid translocase activity and decline in scramblase activity. Findings indicated that garlic has the ability to restore the lifespan of erythrocytes during Pb(2+) exposure.
=>研究(調査)結果
Overview of noun findings
The noun findings has 1 sense (no senses from tagged texts)
1. findings -- (a collection of tools and other articles used by an artisan to make jewelry or
clothing or shoes)
Overview of noun finding
The noun finding has 3 senses (first 3 from tagged texts)
1. (16) determination, finding -- (the act of determining the properties of something, usually by
research or calculation; "the determination of molecular structures")
2. (3) finding -- (the decision of a court on issues of fact or law)
3. (1) finding -- (something that is found; "the findings in the gastrointestinal tract indicate
that he died several hours after dinner"; "an area rich in archaeological findings")
--- WordNet end ---