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299123 occurrences (No.77 in the rank) during 5 years in the PubMed. [cache]

451) Overall, these findings detail the granularity of previously reported factors which may impact susceptibility, clinical severity, and mortality during the course of COVID-19 disease.

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PMID:34228746 DOI:10.1371/journal.pone.0253660

2021 PloS one

* Comorbidities, sequelae, blood biomarkers and their associated clinical outcomes in the Mount Sinai Health System COVID-19 patients.

- With the continuing rise of SARS-CoV2 infection globally and the emergence of various waves in different countries, understanding characteristics of susceptibility to infection, clinical severity, and outcomes remain vital. In this retrospective study, data was extracted for 39,539 patients from the de-identified Mount Sinai Health System COVID-19 database. We assessed the risk of mortality based on the presence of comorbidities and organ-specific sequelae in 7,032 CoV2 positive (+) patients. Prevalence of cardiovascular and metabolic comorbidities was high among SARS-CoV2+ individuals. Diabetes, obesity, coronary artery disease, hypertension, atrial fibrillation, and heart failure all increased overall mortality risk, while asthma did not. Ethnicity modified the risk of mortality associated with these comorbidities. With regards to secondary complications in the setting of infection, individuals with acute kidney injury and acute myocardial injury showed an increase in mortality risk. Cerebral infarcts and acute venous thromboembolic events were not associated with increased risk of mortality. Biomarkers for cardiovascular injury, coagulation, and inflammation were compared between deceased and survived individuals. We found that cardiac and coagulation biomarkers were elevated and fell beyond normal range more often in deceased patients. Several, but not all, inflammatory markers evaluated were increased in deceased patients. In summary, we identified comorbidities and sequelae along with peripheral blood biomarkers that were associated with elevated clinical severity and poor outcomes in COVID-19 patients. Overall, these findings detail the granularity of previously reported factors which may impact susceptibility, clinical severity, and mortality during the course of COVID-19 disease.

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(1)49 suggest	(13)9 support	(25)4 that	(37)2 encourage
(2)40 from	(14)9 will	(26)4 to	(38)2 illuminate
(3)36 of	(15)6 include	(27)4 we	(39)2 it
(4)33 null	(16)6 reveal	(28)3 also	(40)2 may
(5)25 were	(17)6 revealed	(29)3 further	(41)2 open
(6)24 and	(18)5 for	(30)3 presented	(42)2 suggested
(7)21 indicate	(19)5 regarding	(31)3 related	(43)2 the
(8)18 provide	(20)5 showed	(32)3 reported	(44)2 through
(9)17 are	(21)4 can	(33)3 with	(45)2 uncover
(10)15 in	(22)4 demonstrate	(34)2 by	(46)2 underline
(11)11 highlight	(23)4 have	(35)2 confirm
(12)9 on	(24)4 show	(36)2 emphasize

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--- WordNet output for findings --- =>研究(調査)結果 Overview of noun findings The noun findings has 1 sense (no senses from tagged texts) 1. findings -- (a collection of tools and other articles used by an artisan to make jewelry or clothing or shoes) Overview of noun finding The noun finding has 3 senses (first 3 from tagged texts) 1. (16) determination, finding -- (the act of determining the properties of something, usually by research or calculation; "the determination of molecular structures") 2. (3) finding -- (the decision of a court on issues of fact or law) 3. (1) finding -- (something that is found; "the findings in the gastrointestinal tract indicate that he died several hours after dinner"; "an area rich in archaeological findings") --- WordNet end ---