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121) Although in vitro assessments are the first step in the process of development, the safety and efficacy of an IBS strongly depend on validated preclinical research prior to clinical trials.
2015 Journal of tissue engineering and regenerative medicine
* Preclinical evaluation of injectable bone substitute materials.
- Injectable bone substitutes (IBSs) represent an attractive class of ready-to-use biomaterials, both ceramic- and polymer-based, as they offer the potential benefit of minimally invasive surgery and optimal defect filling. Although in vitro assessments are the first step in the process of development, the safety and efficacy of an IBS strongly depend on validated preclinical research prior to clinical trials. However, the selection of a suitable preclinical model for performance evaluation of an IBS remains a challenge, as no gold standard exists to define the best animal model. In order to succeed in this attempt, we identified three stages of development, including (a) proof-of-principle, (b) predictive validity and (c) general scientific legitimacy, and the respective criteria that should be applied for such selection. The second part of this review provides an overview of commonly used animals for IBSs. Specifically, scientific papers published between January 1996 and March 2012 were retrieved that report the use of preclinical models for the evaluation of IBSs in situations requiring bone healing and bone augmentation. This review is meant not only to describe the currently available preclinical models for IBS application, but also to address critical considerations of such multi-factorial evaluation models (including animal species, strain, age, anatomical site, defect size and type of bone), which can be indicative but in most cases edge away from the human reality. Consequently, the ultimate goal is to guide researchers toward a more careful and meaningful interpretation of the results of experiments using animal models and their clinical applications.
=>初めて, 最初の, 第一の, はじめに, 最初, 第1
Overview of noun first
The noun first has 6 senses (first 4 from tagged texts)
1. (9) first, number one -- (the first or highest in an ordering or series; "He wanted to be the
first")
2. (5) first, number one, number 1 -- (the first element in a countable series; "the first of the
month")
3. (1) beginning, commencement, first, outset, get-go, start, kickoff, starting time, showtime,
offset -- (the time at which something is supposed to begin; "they got an early start"; "she knew
from the get-go that he was the man for her")
4. (1) first base, first -- (the fielding position of the player on a baseball team who is stationed
at first of the bases in the infield (counting counterclockwise from home plate))
5. first, first-class honours degree -- (an honours degree of the highest class)
6. first gear, first, low gear, low -- (the lowest forward gear ratio in the gear box of a motor
vehicle; used to start a car moving)
Overview of adj first
The adj first has 6 senses (first 5 from tagged texts)
1. (232) first -- (preceding all others in time or space or degree; "the first house on the right";
"the first day of spring"; "his first political race"; "her first baby"; "the first time"; "the
first meetings of the new party"; "the first phase of his training")
2. (61) first, 1st -- (indicating the beginning unit in a series)
3. (4) inaugural, initiative, initiatory, first, maiden -- (serving to set in motion; "the
magazine's inaugural issue"; "the initiative phase in the negotiations"; "an initiatory step toward
a treaty"; "his first (or maiden) speech in Congress"; "the liner's maiden voyage")
4. (4) beginning, first -- (serving to begin; "the beginning canto of the poem"; "the first verse")
5. (3) first, foremost, world-class -- (ranking above all others; "was first in her class"; "the
foremost figure among marine artists"; "the top graduate")
6. first -- (highest in pitch or chief among parts or voices or instruments or orchestra sections;
"first soprano"; "the first violin section"; "played first horn")
Overview of adv first
The adv first has 4 senses (first 4 from tagged texts)
1. (58) first, firstly, foremost, first of all, first off -- (before anything else; "first we must
consider the garter snake")
2. (40) first, for the first time -- (the initial time; "when Felix first saw a garter snake")
3. (9) first -- (before another in time, space, or importance; "I was here first"; "let's do this
job first")
4. (4) foremost, first -- (prominently forward; "he put his best foot foremost")
--- WordNet end ---