ELIZA

return kwic search for first out of >500 occurrences
378430 occurrences (No.48 in the rank) during 5 years in the PubMed. [no cache] 500 found

14) In conclusion, we demonstrated for the first time that visceral hypersensitivity is associated with alterations of synaptic plasticity in the ACC.

--- ABSTRACT ---

PMID:24108805 DOI:10.1093/cercor/bht273

2015 Cerebral cortex (New York, N.Y. : 1991)

* Facilitation of synaptic transmission in the anterior cingulate cortex in viscerally hypersensitive rats.

- Electrophysiological studies have shown the enhanced response of anterior cingulate cortex (ACC) to colorectal distension in viscerally hypersensitive (VH) rats, which can be observed up to 7 weeks following colonic anaphylaxis, independent of colon inflammation, suggesting a mechanism for learning and triggering of pain memories in the ACC neuronal circuitry. Activity-dependent plasticity in synaptic strength may serve as a key mechanism that reflects cortical plasticity. However, only a few reports have indicated the synaptic plasticity of ACC in vivo. In the present study, electrophysiological recording showed long-lasting potentiation of local field potential in the medial thalamus (MT)-ACC synapses in VH rats. Theta burst stimulation in the MT reliably induced long-term potentiation in the MT-ACC pathway in normal rats, but was occluded in the VH state. Further, repeated tetanization of MT increased ACC neuronal activity and visceral pain responses of normal rats, mimicking VH rats. In conclusion, we demonstrated for the first time that visceral hypersensitivity is associated with alterations of synaptic plasticity in the ACC. The ACC synaptic strengthening in chronic visceral pain may engage signal transduction pathways that are in common with those activated by electrical stimulation, and serves as an attractive cellular model of functional visceral pain.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to first]

(1)32 time	(19)5 meaningful	(37)2 5	(55)2 marriage
(2)21 report	(20)4 line	(38)2 6	(56)2 meta-analysis
(3)11 and	(21)3 14	(39)2 72	(57)2 mitochondrial
(4)11 to	(22)3 3	(40)2 application	(58)2 months
(5)10 time,	(23)3 complete	(41)2 approach	(59)2 myocardial
(6)9 year	(24)3 described	(42)2 article	(60)2 postnatal
(7)8 2	(25)3 in	(43)2 attempt	(61)2 presented
(8)8 molar	(26)3 it	(44)2 choice	(62)2 relapse
(9)8 reported	(27)3 order	(45)2 clinical	(63)2 smear
(10)8 step	(28)3 postoperative	(46)2 component	(64)2 stage
(11)8 we	(29)3 record	(47)2 comprehensive	(65)2 step,
(12)7 case	(30)3 sequenced	(48)2 concern	(66)2 test
(13)6 determined	(31)3 the	(49)2 course	(67)2 that
(14)6 group	(32)3 treatment	(50)2 demonstration	(68)2 therapy
(15)6 study	(33)3 two	(51)2 few	(69)2 trimester
(16)5 dose	(34)3 was	(52)2 intentions	(70)2 trimester,
(17)5 evidence	(35)2 null	(53)2 introduction	(71)2 using
(18)5 generation	(36)2 30	(54)2 left

add keyword

--- WordNet output for first --- =>初めて, 最初の, 第一の, はじめに, 最初, 第1 Overview of noun first The noun first has 6 senses (first 4 from tagged texts) 1. (9) first, number one -- (the first or highest in an ordering or series; "He wanted to be the first") 2. (5) first, number one, number 1 -- (the first element in a countable series; "the first of the month") 3. (1) beginning, commencement, first, outset, get-go, start, kickoff, starting time, showtime, offset -- (the time at which something is supposed to begin; "they got an early start"; "she knew from the get-go that he was the man for her") 4. (1) first base, first -- (the fielding position of the player on a baseball team who is stationed at first of the bases in the infield (counting counterclockwise from home plate)) 5. first, first-class honours degree -- (an honours degree of the highest class) 6. first gear, first, low gear, low -- (the lowest forward gear ratio in the gear box of a motor vehicle; used to start a car moving) Overview of adj first The adj first has 6 senses (first 5 from tagged texts) 1. (232) first -- (preceding all others in time or space or degree; "the first house on the right"; "the first day of spring"; "his first political race"; "her first baby"; "the first time"; "the first meetings of the new party"; "the first phase of his training") 2. (61) first, 1st -- (indicating the beginning unit in a series) 3. (4) inaugural, initiative, initiatory, first, maiden -- (serving to set in motion; "the magazine's inaugural issue"; "the initiative phase in the negotiations"; "an initiatory step toward a treaty"; "his first (or maiden) speech in Congress"; "the liner's maiden voyage") 4. (4) beginning, first -- (serving to begin; "the beginning canto of the poem"; "the first verse") 5. (3) first, foremost, world-class -- (ranking above all others; "was first in her class"; "the foremost figure among marine artists"; "the top graduate") 6. first -- (highest in pitch or chief among parts or voices or instruments or orchestra sections; "first soprano"; "the first violin section"; "played first horn") Overview of adv first The adv first has 4 senses (first 4 from tagged texts) 1. (58) first, firstly, foremost, first of all, first off -- (before anything else; "first we must consider the garter snake") 2. (40) first, for the first time -- (the initial time; "when Felix first saw a garter snake") 3. (9) first -- (before another in time, space, or importance; "I was here first"; "let's do this job first") 4. (4) foremost, first -- (prominently forward; "he put his best foot foremost") --- WordNet end ---