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165) Taken together, present findings provide first evidence for nonadditive effects of age on the relation between complex cognitive abilities and the structural connectivity of mid-dlPFC homologs.
* Predicting planning performance from structural connectivity between left and right mid-dorsolateral prefrontal cortex: moderating effects of age during postadolescence and midadulthood.
- Complex cognitive abilities such as planning are known to critically rely on activity of bilateral mid-dorsolateral prefrontal cortex (mid-dlPFC). However, the functional relevance of the structural connectivity between left and right mid-dlPFC is yet unknown. Here, we applied global tractography to derive streamline counts as estimates of the structural connectivity between mid-dlPFC homologs and related it to planning performance in the Tower of London task across early to midadulthood, assuming a moderating effect of age. Multiple regression analyses with interaction effects revealed that streamline counts between left and right mid-dlPFC were negatively associated with planning performance specifically in early postadolescence. From the fourth life decade on, there was a trend for a reversed, positive association. These differential findings were corroborated by converging results from fractional anisotropy and white-matter density estimates in the genu of the corpus callosum where fibers connecting mid-dlPFC homologs traversed. Moreover, the results for streamline counts were regionally specific, marking the strength of mid-dlPFC connectivity as critical in predicting interindividual differences in planning performance across different stages of adulthood. Taken together, present findings provide first evidence for nonadditive effects of age on the relation between complex cognitive abilities and the structural connectivity of mid-dlPFC homologs.
=>初めて, 最初の, 第一の, はじめに, 最初, 第1
Overview of noun first
The noun first has 6 senses (first 4 from tagged texts)
1. (9) first, number one -- (the first or highest in an ordering or series; "He wanted to be the
first")
2. (5) first, number one, number 1 -- (the first element in a countable series; "the first of the
month")
3. (1) beginning, commencement, first, outset, get-go, start, kickoff, starting time, showtime,
offset -- (the time at which something is supposed to begin; "they got an early start"; "she knew
from the get-go that he was the man for her")
4. (1) first base, first -- (the fielding position of the player on a baseball team who is stationed
at first of the bases in the infield (counting counterclockwise from home plate))
5. first, first-class honours degree -- (an honours degree of the highest class)
6. first gear, first, low gear, low -- (the lowest forward gear ratio in the gear box of a motor
vehicle; used to start a car moving)
Overview of adj first
The adj first has 6 senses (first 5 from tagged texts)
1. (232) first -- (preceding all others in time or space or degree; "the first house on the right";
"the first day of spring"; "his first political race"; "her first baby"; "the first time"; "the
first meetings of the new party"; "the first phase of his training")
2. (61) first, 1st -- (indicating the beginning unit in a series)
3. (4) inaugural, initiative, initiatory, first, maiden -- (serving to set in motion; "the
magazine's inaugural issue"; "the initiative phase in the negotiations"; "an initiatory step toward
a treaty"; "his first (or maiden) speech in Congress"; "the liner's maiden voyage")
4. (4) beginning, first -- (serving to begin; "the beginning canto of the poem"; "the first verse")
5. (3) first, foremost, world-class -- (ranking above all others; "was first in her class"; "the
foremost figure among marine artists"; "the top graduate")
6. first -- (highest in pitch or chief among parts or voices or instruments or orchestra sections;
"first soprano"; "the first violin section"; "played first horn")
Overview of adv first
The adv first has 4 senses (first 4 from tagged texts)
1. (58) first, firstly, foremost, first of all, first off -- (before anything else; "first we must
consider the garter snake")
2. (40) first, for the first time -- (the initial time; "when Felix first saw a garter snake")
3. (9) first -- (before another in time, space, or importance; "I was here first"; "let's do this
job first")
4. (4) foremost, first -- (prominently forward; "he put his best foot foremost")
--- WordNet end ---