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282) For high-pressure homogenization method (high energy method) Design-Expert software was used, and the desirability function was probed to acquire an optimized formulation.
* Formulation of nanoemulsion: a comparison between phase inversion composition method and high-pressure homogenization method.
- There is lot of confusion in the literatures regarding the method of production of nanoemulsion. According to some authors, only the methods using high energy like high-pressure microfluidizer or high-frequency ultra-sonic devices can produce actual nanoemulsions. In contrast to this concept, one research group reported for the first time the preparation of nanoemulsion by a low-energy method. Later on many authors reported about the low-energy emulsification method. The purpose of this work is to formulate, evaluate and compare nanoemulsions prepared using high-energy as well as low-energy method. Nanoemulsions formulated were based on the phase inversion composition technique (low energy method) and were selected from the ternary phase diagram based on the criterion of their being a minimum concentration of S(mix) used in the formulation. For high-pressure homogenization method (high energy method) Design-Expert software was used, and the desirability function was probed to acquire an optimized formulation. No significant difference (p > 0.05) was observed in the globule size of formulations made by each method, but the value of poly-dispersibility index between the two methods was found to be extremely significant (p < 0.001). A very significant difference (p < 0.001) was observed in the drug release from formulations made by each method. More than 60% of the drug was released from all the formulations in the initial 2 h of the dissolution study.
=>1.機能, 関数, 役割, 働き, 2.機能する, 作用する, 働く, 役目を果たす, 3.社交的会合, パーティー, 儀式
Overview of noun function
The noun function has 7 senses (first 3 from tagged texts)
1. (43) function, mathematical function, single-valued function, map, mapping -- ((mathematics) a
mathematical relation such that each element of a given set (the domain of the function) is
associated with an element of another set (the range of the function))
2. (24) function, purpose, role, use -- (what something is used for; "the function of an auger is to
bore holes"; "ballet is beautiful but what use is it?")
3. (7) function, office, part, role -- (the actions and activities assigned to or required or
expected of a person or group; "the function of a teacher"; "the government must do its part"; "play
its role")
4. function -- (a relation such that one thing is dependent on another; "height is a function of
age"; "price is a function of supply and demand")
5. function -- (a formal or official social gathering or ceremony; "it was a black-tie function")
6. affair, occasion, social occasion, function, social function -- (a vaguely specified social
event; "the party was quite an affair"; "an occasion arranged to honor the president"; "a seemingly
endless round of social functions")
7. routine, subroutine, subprogram, procedure, function -- (a set sequence of steps, part of larger
computer program)
Overview of verb function
The verb function has 3 senses (first 3 from tagged texts)
1. (9) function, work, operate, go, run -- (perform as expected when applied; "The washing machine
won't go unless it's plugged in"; "Does this old car still run well?"; "This old radio doesn't work
anymore")
2. (3) serve, function -- (serve a purpose, role, or function; "The tree stump serves as a table";
"The female students served as a control group"; "This table would serve very well"; "His freedom
served him well"; "The table functions as a desk")
3. (1) officiate, function -- (perform duties attached to a particular office or place or function;
"His wife officiated as his private secretary")
--- WordNet end ---