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307) Recently it has been shown that a giant saccular organelle (GSO) of unknown function is present in the axon initial segment (AIS) of an uncharacterized population of pyramidal cells of the rodent neocortex.
* Selective presence of a giant saccular organelle in the axon initial segment of a subpopulation of layer V pyramidal neurons.
- Recently it has been shown that a giant saccular organelle (GSO) of unknown function is present in the axon initial segment (AIS) of an uncharacterized population of pyramidal cells of the rodent neocortex. Using tract-tracing methods and immunocytochemistry, in the present study we show that in rodents this GSO is present in the AIS of subpopulations of layer V pyramidal neurons projecting to various subcortical, non-thalamic targets, including the spinal cord. GSO-containing neurons express SMI32 and some of them are under the control of the Thy-1 gene promoter. In addition, our results demonstrate that the GSO expresses the inositol 1,4,5-triphosphate receptor 1 (IP3R1) and the sarco (endo) plasmic reticulum Ca(2+) ATPase 2, both in rodent and human neocortex. These results indicate the involvement of the GSO in the regulation of Ca(2+) levels in the AIS in a particular subpopulation of layer V neurons that give rise to subcortical non-thalamic descending projections.
=>1.機能, 関数, 役割, 働き, 2.機能する, 作用する, 働く, 役目を果たす, 3.社交的会合, パーティー, 儀式
Overview of noun function
The noun function has 7 senses (first 3 from tagged texts)
1. (43) function, mathematical function, single-valued function, map, mapping -- ((mathematics) a
mathematical relation such that each element of a given set (the domain of the function) is
associated with an element of another set (the range of the function))
2. (24) function, purpose, role, use -- (what something is used for; "the function of an auger is to
bore holes"; "ballet is beautiful but what use is it?")
3. (7) function, office, part, role -- (the actions and activities assigned to or required or
expected of a person or group; "the function of a teacher"; "the government must do its part"; "play
its role")
4. function -- (a relation such that one thing is dependent on another; "height is a function of
age"; "price is a function of supply and demand")
5. function -- (a formal or official social gathering or ceremony; "it was a black-tie function")
6. affair, occasion, social occasion, function, social function -- (a vaguely specified social
event; "the party was quite an affair"; "an occasion arranged to honor the president"; "a seemingly
endless round of social functions")
7. routine, subroutine, subprogram, procedure, function -- (a set sequence of steps, part of larger
computer program)
Overview of verb function
The verb function has 3 senses (first 3 from tagged texts)
1. (9) function, work, operate, go, run -- (perform as expected when applied; "The washing machine
won't go unless it's plugged in"; "Does this old car still run well?"; "This old radio doesn't work
anymore")
2. (3) serve, function -- (serve a purpose, role, or function; "The tree stump serves as a table";
"The female students served as a control group"; "This table would serve very well"; "His freedom
served him well"; "The table functions as a desk")
3. (1) officiate, function -- (perform duties attached to a particular office or place or function;
"His wife officiated as his private secretary")
--- WordNet end ---