ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for functional out of >500 occurrences
267449 occurrences (No.100 in the rank) during 5 years in the PubMed. [cache]
111) Our transplantation experiments using BMCs obtained from ischemic donor rats showed functional and structural recovery during the chronic stage of stroke.
--- ABSTRACT ---
PMID:24152766 DOI:10.3727/096368913X674666
2015 Cell transplantation
* Enhanced recovery from chronic ischemic injury by bone marrow cells in a rat model of ischemic stroke.
- Even after decades of intensive studies, therapeutic options for patients with stroke are rather limited. Thrombolytic drugs effectively treat the very acute stage of stroke, and several neuroprotectants that are designed to treat secondary injury following stroke are being tested in clinical trials. However, these pharmacological approaches primarily focus on acute stroke recovery, and few options are available for treating chronic stroke patients. In recent years, stem cell-mediated regenerative approaches have emerged as promising therapeutic strategies for treating the chronic stage of stroke. In this study, we examined whether systemically administered bone marrow cells (BMCs) could have beneficial effects in a rat model of chronic ischemia. Our transplantation experiments using BMCs obtained from ischemic donor rats showed functional and structural recovery during the chronic stage of stroke. BMC-mediated neural proliferation was prominent in the brains of rats with chronic stroke, and most of the new cells eventually became neurons instead of astrocytes. BMC-mediated enhanced neural proliferation coincided with a significant reduction (∼50%) in the number of activated microglia, which is consistent with previous reports of enhanced neural proliferation being linked to microglial inactivation. Strikingly, approximately 57% of the BMCs that infiltrated the chronic ischemic brain were CD25(+) cells, suggesting that these cells may exert the beneficial effects associated with BMC transplantation. Based on the reported anti-inflammatory role of CD25(+) regulatory T-cells in acute experimental stroke, we propose a working model delineating the positive effects of BMC transplantation during the chronic phase of stroke; infiltrating BMCs (mostly CD25(+) cells) reduce activated microglia, which leads to enhanced neural proliferation and enhanced recovery from neuronal damage in this rat model of chronic stroke. This study provides valuable insights into the effect of BMC transplantation in the chronic ischemic brain, which may lead to the development of effective therapy for chronic stroke patients who currently lack satisfactory therapeutic options.
--- ABSTRACT END ---
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[frequency of next (right) word to functional]
(1)50 magnetic (18)4 gastrointestinal (35)3 integration (52)2 connections
(2)38 connectivity (19)4 outcome (36)3 interactions (53)2 differentiation
(3)29 and (20)4 outcomes (37)3 movement (54)2 domains
(4)8 limitations (21)4 relationships (38)3 single (55)2 endurance
(5)7 network (22)4 unit (39)3 status (56)2 health
(6)7 recovery (23)3 Assessment (40)3 status, (57)2 imaging
(7)7 role (24)3 MRI (41)3 studies (58)2 impact
(8)6 changes (25)3 Well-Being (42)2 CD133 (59)2 integrity
(9)6 results (26)3 activation (43)2 HL (60)2 losses
(10)5 alterations (27)3 brain (44)2 ability (61)2 networks
(11)5 limitation (28)3 consequences (45)2 activity (62)2 neuronal
(12)5 neuroimaging (29)3 coupling (46)2 analyses (63)2 organization
(13)5 properties (30)3 decline (47)2 as (64)2 parameters
(14)5 theory (31)3 deficits (48)2 assays (65)2 roles
(15)4 capacity (32)3 differences (49)2 assessment (66)2 significance
(16)4 connectivity, (33)3 impairment (50)2 characteristics (67)2 specialization
(17)4 foods (34)3 improvement (51)2 cognitive

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--- WordNet output for functional --- =>機能の, 関数の, 機能する, 機能上の, 実用的な, 機能的な Overview of adj functional The adj functional has 6 senses (first 2 from tagged texts) 1. (3) functional -- (designed for or capable of a particular function or use; "a style of writing in which every word is functional"; "functional architecture") 2. (1) functional -- (involving or affecting function rather than physiology; "functional deafness") 3. functional -- (relating to or based on function especially as opposed to structure; "the problem now is not a constitutional one; it is a functional one"; "delegates elected on a functional rather than a geographical basis") 4. functional, usable, useable, operable, operational -- (fit or ready for use or service; "the toaster was still functional even after being dropped"; "the lawnmower is a bit rusty but still usable"; "an operational aircraft"; "the dishwasher is now in working order") 5. functional -- (designed for or adapted to a function or use; "functional education selects knowledge that is concrete and usable rather than abstract and theoretical"; "functional architecture") 6. running, operative, functional, working -- ((of e.g. a machine) performing or capable of performing; "in running (or working) order"; "a functional set of brakes") --- WordNet end ---