ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for functional out of >500 occurrences
267449 occurrences (No.100 in the rank) during 5 years in the PubMed. [cache]
64) The pre-HD group showed longitudinal decreased functional connectivity between left DLPFC and caudate during both 1-BACK and 2-BACK performance.
--- ABSTRACT ---
PMID:24240602 DOI:10.1007/s00429-013-0670-z
2015 Brain structure & function
* Functional changes during working memory in Huntington's disease: 30-month longitudinal data from the IMAGE-HD study.
- We characterized 30-month longitudinal change in functional activation and connectivity during working memory in premanifest (pre-HD) and symptomatic (symp-HD) Huntington's disease (HD). In a case-control longitudinal study (baseline, 18 months, and 30 months), we compared change in fMRI activity over time during working memory in 22 pre-HD, 11 symp-HD, and 20 control participants. Outcome measures were BOLD (blood-oxygen-level-dependent) activity during 1-BACK and 2-BACK working memory and functional connectivity between dorsolateral prefrontal cortex (DLPFC) and caudate. Compared with controls, the pre-HD group showed significantly increased activation longitudinally during 1-BACK in the left DLPFC and medial frontal cortex, and further increased activation during 2-BACK in the bilateral caudate, putamen, and temporal cortex. Longitudinal change in symp-HD was not significantly different from controls. Longitudinal changes in pre-HD were associated with disease burden and years to onset. The pre-HD group showed longitudinal decreased functional connectivity between left DLPFC and caudate during both 1-BACK and 2-BACK performance. We provide an evidence for longitudinal changes in BOLD activity during working memory prior to clinical manifestations of HD. The ability to increase activation in the prefrontal cortex over time may represent an early compensatory response during the premanifest stage, which may reflect an early marker for clinically relevant functional changes in HD.
--- ABSTRACT END ---
[
right
kwic]
[frequency of next (right) word to functional]
(1)50 magnetic (18)4 gastrointestinal (35)3 integration (52)2 connections
(2)38 connectivity (19)4 outcome (36)3 interactions (53)2 differentiation
(3)29 and (20)4 outcomes (37)3 movement (54)2 domains
(4)8 limitations (21)4 relationships (38)3 single (55)2 endurance
(5)7 network (22)4 unit (39)3 status (56)2 health
(6)7 recovery (23)3 Assessment (40)3 status, (57)2 imaging
(7)7 role (24)3 MRI (41)3 studies (58)2 impact
(8)6 changes (25)3 Well-Being (42)2 CD133 (59)2 integrity
(9)6 results (26)3 activation (43)2 HL (60)2 losses
(10)5 alterations (27)3 brain (44)2 ability (61)2 networks
(11)5 limitation (28)3 consequences (45)2 activity (62)2 neuronal
(12)5 neuroimaging (29)3 coupling (46)2 analyses (63)2 organization
(13)5 properties (30)3 decline (47)2 as (64)2 parameters
(14)5 theory (31)3 deficits (48)2 assays (65)2 roles
(15)4 capacity (32)3 differences (49)2 assessment (66)2 significance
(16)4 connectivity, (33)3 impairment (50)2 characteristics (67)2 specialization
(17)4 foods (34)3 improvement (51)2 cognitive

add keyword

--- WordNet output for functional --- =>機能の, 関数の, 機能する, 機能上の, 実用的な, 機能的な Overview of adj functional The adj functional has 6 senses (first 2 from tagged texts) 1. (3) functional -- (designed for or capable of a particular function or use; "a style of writing in which every word is functional"; "functional architecture") 2. (1) functional -- (involving or affecting function rather than physiology; "functional deafness") 3. functional -- (relating to or based on function especially as opposed to structure; "the problem now is not a constitutional one; it is a functional one"; "delegates elected on a functional rather than a geographical basis") 4. functional, usable, useable, operable, operational -- (fit or ready for use or service; "the toaster was still functional even after being dropped"; "the lawnmower is a bit rusty but still usable"; "an operational aircraft"; "the dishwasher is now in working order") 5. functional -- (designed for or adapted to a function or use; "functional education selects knowledge that is concrete and usable rather than abstract and theoretical"; "functional architecture") 6. running, operative, functional, working -- ((of e.g. a machine) performing or capable of performing; "in running (or working) order"; "a functional set of brakes") --- WordNet end ---