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- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

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298283 occurrences (No.79 in the rank) during 5 years in the PubMed. [no cache] 500 found
25) Differentiated PC12 cells were characterized by highly aligned and longer neurites on parallel PHB fibres with respect to random fibres, thereby demonstrating the suitability of parallel PHB fibres for further studies in peripheral nervous system regeneration.
--- ABSTRACT ---
PMID:23086861 DOI:10.1002/term.1623
2015 Journal of tissue engineering and regenerative medicine
* PC12 neuron-like cell response to electrospun poly( 3-hydroxybutyrate) substrates.
- In the last decade, the importance of topographic properties of extracellular environments has been shown to be essential to addressing cell response, especially when replacing damaged tissues with functional constructs obtained in vitro. In the current study, densely packed sub-micron poly(3-hydroxybutyrate) (PHB) fibres were electrospun with random and parallel orientations. PC12 pheochromocytoma cells that mimic central dopaminergic neurons and represent a model for neuronal differentiation were cultured on collagen-coated fibres to evaluate cell response dependence on substrate topography. Cell adhesion, viability and proliferation, as well as dopamine production were evaluated after three days since seeding. Cell differentiation was examined in terms of neurite number, orientation and length 6 days after administration of nerve growth factor (NGF). Results showed that proliferating PC12 cells secreted a higher quantity of dopamine on fibres with respect to control cultures and as a result, a possible use of PHB fibres was considered for cell transplantation in the central nervous system when local production of dopamine is impaired. Differentiated PC12 cells were characterized by highly aligned and longer neurites on parallel PHB fibres with respect to random fibres, thereby demonstrating the suitability of parallel PHB fibres for further studies in peripheral nervous system regeneration.
--- ABSTRACT END ---
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(1)39 studies (16)4 developed (31)2 analyses (46)2 insights
(2)32 research (17)4 in (32)2 analyzed (47)2 monitoring
(3)18 investigation (18)4 supported (33)2 application (48)2 optimization
(4)18 study (19)3 *null* (34)2 as (49)2 prospective
(5)11 the (20)3 a (35)2 assessed (50)2 protection
(6)10 investigations (21)3 clinical (36)2 complications (51)2 spread
(7)8 analysis (22)3 evaluation (37)2 divided (52)2 suggests
(8)7 evidence (23)3 exploration (38)2 elucidate (53)2 supporting
(9)7 phylogenetic (24)3 explore (39)2 enhance (54)2 supports
(10)6 explored (25)3 for (40)2 episodes (55)2 taxonomic
(11)5 development (26)3 increased (41)2 evaluated (56)2 that
(12)5 support (27)3 investigate (42)2 examination (57)2 used
(13)5 validation (28)3 molecular (43)2 identification
(14)4 by (29)3 understand (44)2 improvement
(15)4 confirmed (30)2 advances (45)2 increase

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--- WordNet output for further --- =>1.さらにずっと, さらに先に, 一層遠く, その上, 更に, もっと遠い, なお一層の, さらに遠く, もっと先に, いっそうはるかに, さらにまた, さらになお(furthermore), 2.進める, 助成する, 促進する Overview of verb further The verb further has 2 senses (first 2 from tagged texts) 1. (7) foster, further -- (promote the growth of; "Foster our children's well-being and education") 2. (2) promote, advance, boost, further, encourage -- (contribute to the progress or growth of; "I am promoting the use of computers in the classroom") Overview of adj further The adj further has 1 sense (first 1 from tagged texts) 1. (2) further, farther -- (more distant in especially degree; "nothing could be further from the truth"; "further from our expectations"; "farther from the truth"; "farther from our expectations") Overview of adv further The adv further has 3 senses (first 3 from tagged texts) 1. (33) further, farther -- (to or at a greater extent or degree or a more advanced stage (`further' is used more often than `farther' in this abstract sense); "further complicated by uncertainty about the future"; "let's not discuss it further"; "nothing could be further from the truth"; "they are further along in their research than we expected"; "the application of the law was extended farther"; "he is going no farther in his studies") 2. (10) further -- (in addition or furthermore; "if we further suppose"; "stated further that he would not cooperate with them"; "they are definitely coming; further, they should be here already") 3. (1) farther, further -- (to or at a greater distance in time or space (`farther' is used more frequently than `further' in this physical sense); "farther north"; "moved farther away"; "farther down the corridor"; "the practice may go back still farther to the Druids"; "went only three miles further"; "further in the future") Overview of adv far The adv far has 5 senses (first 4 from tagged texts) 1. (61) far -- (to a considerable degree; very much; "a far far better thing that I do"; "felt far worse than yesterday"; "eyes far too close together") 2. (39) far -- (at or to or from a great distance in space; "he traveled far"; "strayed far from home"; "sat far away from each other") 3. (22) far -- (at or to a certain point or degree; "I can only go so far before I have to give up"; "how far can we get with this kind of argument?") 4. (3) far -- (remote in time; "if we could see far into the future"; "all that happened far in the past") 5. far -- (to an advanced stage or point; "a young man who will go very far") --- WordNet end ---