kwic
further
further
right
off
ON
293
1
100
500
strict
ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for further out of >500 occurrences
298283 occurrences (No.79 in the rank) during 5 years in the PubMed. [cache]
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of next (right) word to further]
298283 occurrences (No.79 in the rank) during 5 years in the PubMed. [cache]
| 293) Further insight on the metabolism of AGEs and their dicarbonyls precursors, and their roles in colorectal cancer development is needed. |
| PMID:33780524 DOI:10.1093/carcin/bgab026 |
| 2021 Carcinogenesis |
| * Plasma concentrations of advanced glycation end-products and colorectal cancer risk in the EPIC study. |
| - Advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed by the non-enzymatic reaction between amino acids and reducing sugars, or dicarbonyls as intermediate compounds. Experimental studies suggest that AGEs may promote colorectal cancer, but prospective epidemiologic studies are inconclusive. We conducted a case-control study nested within a large European cohort. Plasma concentrations of three protein-bound AGEs-Nε-(carboxy-methyl)lysine (CML), Nε-(carboxy-ethyl)lysine (CEL) and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1)-were measured by ultra-performance liquid chromatography-tandem mass spectrometry in baseline samples collected from 1378 incident primary colorectal cancer cases and 1378 matched controls. Multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were computed using conditional logistic regression for colorectal cancer risk associated with CML, CEL, MG-H1, total AGEs, and [CEL+MG-H1: CML] and [CEL:MG-H1] ratios. Inverse colorectal cancer risk associations were observed for CML (OR comparing highest to lowest quintile, ORQ5 versus Q1 = 0.40, 95% CI: 0.27-0.59), MG-H1 (ORQ5 versus Q1 = 0.73, 95% CI: 0.53-1.00) and total AGEs (OR Q5 versus Q1 = 0.52, 95% CI: 0.37-0.73), whereas no association was observed for CEL. A higher [CEL+MG-H1: CML] ratio was associated with colorectal cancer risk (ORQ5 versus Q1 = 1.91, 95% CI: 1.31-2.79). The associations observed did not differ by sex, or by tumour anatomical sub-site. Although individual AGEs concentrations appear to be inversely associated with colorectal cancer risk, a higher ratio of methylglyoxal-derived AGEs versus those derived from glyoxal (calculated by [CEL+MG-H1: CML] ratio) showed a strong positive risk association. Further insight on the metabolism of AGEs and their dicarbonyls precursors, and their roles in colorectal cancer development is needed. |
[
right
kwic]
(1)83  research |
(16)4 validation |
(31)2 and |
(46)2 high-quality |
| (2)43 studies |
(17)3 confirmed |
(32)2 attention |
(47)2 inform |
| (3)22 investigation |
(18)3 demonstrate |
(33)2 characterization |
(48)2 insight |
| (4)9 analysis |
(19)3 demonstrated |
(34)2 clinical |
(49)2 reduce |
| (5)9 study |
(20)3 highlight |
(35)2 considerations |
(50)2 research, |
| (6)7 the |
(21)3 identify |
(36)2 develop |
(51)2 screening |
| (7)7 work |
(22)3 in |
(37)2 developing |
(52)2 showed |
| (8)5 development |
(23)3 investigated |
(38)2 discussion |
(53)2 structure-based |
| (9)5 evidence |
(24)3 investigations |
(39)2 divided |
(54)2 studied |
| (10)4 evaluate |
(25)3 literature |
(40)2 enhanced |
(55)2 supported |
| (11)4 evaluation |
(26)3 our |
(41)2 evaluated |
(56)2 tested |
| (12)4 exploration |
(27)3 show |
(42)2 evaluations |
(57)2 this |
| (13)4 explore |
(28)3 we |
(43)2 examined |
(58)2 understand |
| (14)4 improve |
(29)2 aid |
(44)2 explored |
(59)2 understanding |
| (15)4 investigate |
(30)2 analyses |
(45)2 extend |
add keyword
--- WordNet output for further ---